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Derm News: 2007.22(9)

Combined 0.1% Retinaldehyde/ 6% Glycolic Acid Cream in Prophylaxis and Treatment of Acne Scarring

Dermatology, 214(3):260-267
Brigitte Dreno, Andreas Katsambas, Carlo Pelfini, Daniel Plantier, Eliane Jancovici, Virginie Ribet, Thérèse Nocera, Pierre Morinet, Amir Khammari


Acne often results in permanent, badly tolerated, difficult to treat scars.


To evaluate the efficacy and safety of a 0.1% retinaldehyde/6% glycolic acid (RALGA) cream at preventing and treating acne scarring in patients previously treated for moderate acne.


A double-blind vehicle-controlled study was conducted in 145 patients randomized to apply RALGAor vehicle cream every evening for 3 months. Global scarring score and patient's assessment of global efficacy, then residual acne lesions, quality of life and tolerance were evaluated at inclusion and each month until study completion.


Global scarring score, number of inflammatory lesions and comedones significantly improved in each group from day 28 (p < 0.0001). Number of inflammatory lesions were significantly decreased only in the RALGA group. RALGA cream was more efficient than vehicle on scarring after 3 months in compliant patients (p = 0.007) due to erythema and hyperpigmentation improvement.


RALGA cream is efficient at preventing and treating acne scarring in patients with moderate acne.

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The Derm News service provided by the Editorial Consultants of Skin Therapy Letter© and its founding editor Dr. Stuart Maddin.