Skin Therapy Letter HOME
Written for dermatologists by dermatologists. Indexed by the US National Library of Medicine.
Skin Information
Skin Therapy Letter About STL Subscribe Today SkinCareGuide Network Site Map

Derm News: 2007.4(3)

Psoriasis: a possible risk factor for development of coronary artery calcification

British Journal of Dermatology 156 (2), 271-276.
R.J. Ludwig, C. Herzog, A. Rostock, F.R. Ochsendorf, T.M. Zollner, D. Thaci, R. Kaufmann, T.J. Vogl, W-H. Boehncke


Psoriasis is a chronic inflammatory skin disorder affecting about 2% of white-skinned individuals. Epidemiological data on the prevalence and degree of coronary artery calcification (CAC) as an indicator for cardiovascular diseases in patients with psoriasis are contradictory.


To study the prevalence and degree of CAC as an indicator for cardiovascular diseases in 32 patients with psoriasis matched for age, sex and risk factors to an equally sized control population.


Noncontrast-enhanced 16-row spiral computed tomography was performed in patients and controls.


We found a significantly increased prevalence (594% vs. 281%, P = 0015) and severity (CAC score according to Agatston 37 vs. 00, P = 0019) of CAC in patients with psoriasis. Multiple linear regression calculations identified psoriasis as a likely independent risk factor for CAC.


Our results point towards the potentially systemic nature of the inflammatory processes underlying the pathogenesis of psoriasis, which may therefore be considered a potentially severe systemic disease.

    Back to Current Volume:   Dermatology News 2007.4

The Derm News service provided by the Editorial Consultants of Skin Therapy Letter© and its founding editor Dr. Stuart Maddin.