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Derm News: 2007.4(3)

Psoriasis: a possible risk factor for development of coronary artery calcification

British Journal of Dermatology 156 (2), 271-276.
R.J. Ludwig, C. Herzog, A. Rostock, F.R. Ochsendorf, T.M. Zollner, D. Thaci, R. Kaufmann, T.J. Vogl, W-H. Boehncke

Background

Psoriasis is a chronic inflammatory skin disorder affecting about 2% of white-skinned individuals. Epidemiological data on the prevalence and degree of coronary artery calcification (CAC) as an indicator for cardiovascular diseases in patients with psoriasis are contradictory.

Objectives

To study the prevalence and degree of CAC as an indicator for cardiovascular diseases in 32 patients with psoriasis matched for age, sex and risk factors to an equally sized control population.

Methods

Noncontrast-enhanced 16-row spiral computed tomography was performed in patients and controls.

Results

We found a significantly increased prevalence (594% vs. 281%, P = 0015) and severity (CAC score according to Agatston 37 vs. 00, P = 0019) of CAC in patients with psoriasis. Multiple linear regression calculations identified psoriasis as a likely independent risk factor for CAC.

Conclusions

Our results point towards the potentially systemic nature of the inflammatory processes underlying the pathogenesis of psoriasis, which may therefore be considered a potentially severe systemic disease.


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The Derm News service provided by the Editorial Consultants of Skin Therapy Letter© and its founding editor Dr. Stuart Maddin.