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Derm News: 2007.5(4)

Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde-containing deodorants

Contact Dermatitis 56 (3), 146-150. Volume 56 Issue 3 Page 146 - March 2007
Pia Haslund Jørgensen, Charlotte Devantier Jensen, Suresh Rastogi, Klaus Ejner Andersen, Jeanne Duus Johansen


Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC) known as Lyral® is a frequent allergen. It is used in more than 50% of marketed deodorants. The aim of the present study was to determine elicitation thresholds for HICC under simulated conditions of deodorant use. 15 patients with previously diagnosed contact allergy to HICC were patch tested with 5 solutions of HICC-scented and HICC-unscented deodorants.

Patients and 10 healthy controls performed a use test in the axillae using deodorants scented with HICC in increasing concentrations and unscented deodorants as control. The concentration of HICC was increased every second week (200, 600, and 1800 p.p.m.) until either a reaction developed or for 6 weeks.

14 patients completed the study, and all developed unilateral eczema from the HICC-containing deodorant, while controls were all negative (P = 0.004). In 9/14 patients, a positive use test developed during the first 2 weeks to the deodorant containing 200 p.p.m. HICC. Positive correlations were found between the day of positive use and patch test threshold concentration of the HICC solutions (r = 0.71, P = 0.01) as well as the patch test thresholds of the HICC-scented deodorants (r = 0.74, P = 0.007). In conclusion, HICC elicits allergic contact dermatitis in a high proportion of sensitized individuals at common usage concentrations in deodorants.

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The Derm News service provided by the Editorial Consultants of Skin Therapy Letter© and its founding editor Dr. Stuart Maddin.