Derm News: 2007.8(2)

Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris

Volume 56, Issue 3, Pages 439.e1-439.e10 (March 2007) J Am Acad Dermatol
Zoe D. Draelos, Eric CarterJ. Michael MaloneyBoni Elewski, Yves Poulin, Charles Lynde, Steven Garrett
ABSTRACT

Background

A new aqueous gel formulation of dapsone has been developed that allows clinically-effective doses of dapsone to be administered topically with minimal systemic absorption.

Objectives

The goal of these studies was to evaluate the efficacy and safety of dapsone gel, 5% in the treatment of acne.

Methods

Patients 12 years of age and older with acne vulgaris (N = 3010) participated in two identically-designed 12-week, randomized, double-blind studies of twice-daily monotherapy with dapsone gel, 5%, versus a vehicle gel.

Results

Dapsone gel-treated patients achieved superior results in terms of the investigator's global acne assessment (P < .001) and the mean percentage reduction in inflammatory, noninflammatory, and total lesion counts (all, P < .001) at week 12. Reductions in inflammatory lesion counts favoring dapsone gel over vehicle were apparent as early as 2 weeks and reached statistical significance by 4 weeks. No clinically significant changes in laboratory parameters, including hemoglobin, even among glucose-6-phosphate dehydrogenase-deficient patients, were observed. Adverse events were comparable between the treatment groups and rarely led to discontinuation.

Limitations

Adjunctive topical treatments and their impact on acne were not studied in this trial.

Conclusions

Dapsone gel, 5% appears to be an effective, safe, and well-tolerated treatment for acne vulgaris, with a rapid onset of action.

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The Derm News service provided by the Editorial Consultants of Skin Therapy Letter^© and its founding editor Dr. Stuart Maddin.