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Skin Barrier Repair in the Management of Atopic Dermatitis

Reza Alizadehfar, MD, FRCPC

Division of Clinical Immunology and Allergy, McGill University, Montréal, QC, Canada
Montréal Children’s Hospital, Montréal, QC, Canada

Background

The term “atopy” was first coined by Cooke and Coca in 1923, derived from the Greek word atopos, which means out of place and denotes an immune reaction that is “strange or eccentric”. Atopic dermatitis (AD) is a chronic, waxing and waning, often symmetric inflammatory eruption that is characterized by pruritus and xerosis (dry skin). AD frequently emerges in the first few months of life, but its prevalence decreases with increasing age. It has been reported to affect up to 15% of children worldwide1 and can persist into adulthood. This pathology is probably caused by the interplay of genetic and environmental factors.

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Genetic Factors in Atopic Dermatitis

  • A strong genetic involvement in AD has been clearly established.
  • Linkage analysis studies and the examination of polymorphisms in a number of candidate genes have identified several chromosomal loci and potential genes as possible susceptibility factors.
  • The genetic variants in these loci and genes are postulated to be involved in
    • immunoglobulin E (IgE) antibody production
    • regulation of the immune response in the skin and mucosa
    • epidermal barrier dysfunction, via modulation of epidermal maturation.

Environmental Factors in Atopic Dermatitis

  • Genetic factors alone, however, cannot explain the results of epidemiological studies showing the recent significant increase in prevalence of atopic dermatitis, especially in industrialized countries.
  • Therefore, a key role for environmental factors in mediating disease expression has been suggested.
  • Allergic sensitization to house dust mites and some foods may play an important etiologic role in some patients.
  • However, non-allergic factors may also contribute to the pathophysiology of AD by influencing dysregulation, resulting in disruption of the skin barrier. These include:
    • low environmental humidity level
    • Staphylococcus aureus (S. aureus) colonization
    • exposure (or the absence of it) to certain microbial factors in early infancy
    • exposure to pollutants, detergents, and other irritants
    • excessive heat.

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The Impairment of the Barrier Function

  • The epidermis of the skin functions not only as a physical and anatomical barrier, but also as a vast immunological organ.
  • This barrier constantly protects against the entry of different microbes, allergens, and irritants.
  • In AD, a dysfunctional skin barrier has been shown to provoke increased trans-epidermal water loss (TEWL), resulting in pronounced cutaneous dehydration.
  • Such a damaged barrier can allow allergens, microbes, and irritants to penetrate the skin and cause a proinflammatory reaction that typically characterizes AD.
  • The extent of barrier dysfunction strongly correlates with the degree of inflammation within AD lesions.2
  • The stratum corneum (SC) of the skin has been compared to a brick wall, consisting of terminally differentiated keratinocytes (bricks) that are surrounded by a matrix of specialized lipids.
    • The major lipids in the SC are:
      • ceramides (50% by mass)
      • cholesterol (25% by mass)
      • fatty acids (10-20% by mass).
    • These elements create a barrier that helps to
      • keep water within the body
      • prevent the entrance of pathogens and allergens.
  • It has been shown that AD patients have reduced levels of the SC lipids (e.g., ceramides).3,4
  • This barrier defect affects not only the involved, but also the uninvolved skin, which correlates with a decrease in the ceramide fraction of the SC.
  • Furthermore, the epidermal dysfunction in AD may also be attributable to several factors including:
    • an altered enzymatic activity
    • an altered pH of the skin
    • an impaired epidermal differentiation and an abnormal expression of structural proteins involved in the cornification process.
  • Genetic abnormalities in protease inhibitor expression and reduced levels of cornified envelope proteins, such as filaggrin,5 fuel the skin damage seen in eczematoid conditions.
  • Stress may also aggravate this barrier dysfunction by the production of endogenous glucocorticoids, which suppress epidermal lipid synthesis.
  • The skin barrier is further damaged by exposure to proteases from house dust mites and S. aureus.
  • Lastly, the intense itching and extensive scratching that is associated with AD can also be an important factor leading to the disruption of the cutaneous barrier.

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Options for Management

A range of treatments exist for atopic dermatitis, depending on the severity of the disease.

Non-pharmacological Factors

  • Flare-ups of AD can be reduced by:
    • wearing soft cotton clothing
    • washing clothes with mild detergents
    • avoiding the use of fabric softeners
    • controlling the ambient temperature and humidity of the home
    • implementing avoidance measures to decrease exposure to dust mites in sensitized individuals
    • more rarely, avoiding specific foods in sensitized patients. If a food trigger is suspected, it may be useful to consult an allergist.
  • It is important to emphasize that no good evidence supports highly restrictive diets, which might have a significant psychological impact and can lead to malnutrition.
  • Educational programs have demonstrated significant improvement in AD severity and treatment satisfaction in intervention groups compared with control groups.6

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Emollients

  • Emollients soften and soothe the skin.
  • They are petroleum based gels.
  • There is no strong evidence that emollients improve AD directly.
  • However, emollients are widely recommended because they improve the appearance and symptoms of dry skin that is commonly present in AD.7
  • Studies have shown that emollients may reduce the need for topical steroids and enhance the therapeutic response to them.8,9
  • In the absence of good studies showing the superiority of one emollient over another, patient preference should guide their usage.

Topical Corticosteroids

  • For several decades, topical corticosteroids have been the mainstay of treatment for AD flare-ups.
  • A number of agents are available in various vehicles, potencies, and concentrations.
  • Low-potency agents should be used in infants and on sensitive skin areas (e.g., face, neck, groin, and axillae) in order to minimize side-effects, such as skin atrophy, acne, and adverse systemic effects.
  • Topical corticosteroids should be used for the shortest duration and at the lowest potency possible, while still allowing good control of flare-ups, in order to minimize adverse effects.
  • Conversely, misinformed patients and/or parents demonstrating steroid phobia should be informed that withholding appropriate treatment affects their/ their children’s wellbeing and unnecessarily prolongs the course of sometimes debilitating disease.

Topical Calcineurin Inhibitors (TCIs)

  • TCIs are indicated in the management of
    • mild to moderate AD (pimecrolimus)
    • moderate to severe AD (tacrolimus).
  • TCIs inhibit T cell activation and release of cytokines involved in the pro-inflammatory cascade of AD.
  • Their side-effects include skin irritation and burning at the start of therapy, but usually subside with time.
  • Their long-term safety is unknown and amid rare reports of malignancies they should only be used in patients who are unresponsive or show unacceptable side-effects with classic therapy.10,11

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Oral Antihistamines

  • There has been a lack of evidence supporting the use of sedative or non-sedative antihistamines for the treatment of atopic dermatitis.
  • The first generation antihistamines (diphenhydramine and hydroxyzine) are sometimes recommended at night for their sedative effects.

Antimicrobial Agents

  • Secondary superinfection with S. aureus is common and is treated with short courses of antibiotics with anti-staphylococcus coverage.
  • Antiseptic baths have been advocated by some experts in those chronically colonized.

Barrier Repair Creams

  • Given the importance of the dysregulated barrier function in AD, the use of topical agents aimed at accelerating its improvement represents a new therapeutic approach.
  • As important as emollients are for the alleviation of AD symptoms, these agents may be ineffective at correcting TEWL and the ceramide deficiency resulting from the defective skin barrier of AD patients.
  • The efficacy and tolerability of new ceramide-dominant skin repair creams with a more physiologic 3:1:1 ratio of ceramides, free fatty acids, and cholesterol have been studied in two company sponsored trials.12,13
  • In one multicenter, investigator-blinded, randomized pediatric study using EpiCeramR skin barrier cream, similar efficacy was demonstrated when compared with the mid-potency steroid fluticasone propionate 0.05%.12 No significant adverse events were observed in either treatment arms. However, 4 of 59 patients in the barrier group experienced an initial flare-up that required short-term fluticasone cream.
  • EpiCeramR, a steroid-free, lipid-based barrier repair cream was approved by Health Canada in September 2009 and is only available by prescription. Use is indicated for AD patients .6 months of age.
  • Studies on concomitant use of both topical steroids and skin barrier repair creams are not yet available.

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Conclusion

Because of the better appreciated role of the skin barrier in AD disease pathogenesis, use of agents that can stabilize epidermal defenses may reduce the current exclusive dependence on topical steroids and immunomodulators. These barrier repair creams do not target inflammation directly, but rather act at an earlier stage in the disease process to normalize the barrier function and reduce pro-inflammatory signaling. This approach could potentially lead to better treatment outcomes with lesser side-effects.

References
  1. Williams H, et al. J Allergy Clin Immunol 103(1 Pt 1): 125-38 (1999 Jan).
  2. Lebwohl M, et al. Cutis 76(6 Suppl):7-12 (2005 Dec).
  3. Imokawa G. J Am Acad Dermatol 45(1 Suppl):S29-32 (2001 Jul).
  4. Pilgram GS, et al. J Invest Dermatol 117(3):710-7 (2001 Sep).
  5. Palmer CN, et al. Nat Genet 38(4):441-6 (2006 Apr).
  6. Staab D, et al. Pediatr Allergy Immunol 13(2):84-90 (2002 Apr).
  7. Hanifin JM, et al. J Am Acad Dermatol 50(3):391-404 (2004 Mar).
  8. Lucky AW, et al. Pediatr Dermatol 14(4):321-4 (1997 Jul-Aug).
  9. Kantor I, et al. Today Ther Trends 11:157-66 (1993).
  10. US FDA Alert for Healthcare Professionals: Pimecrolimus. Available at: http://www.fda.gov/Drugs/ DrugSafety/PostmarketDrugSafetyInformationforPatients andProviders/ucm153525.htm. Accessed: August 2, 2010.
  11. US FDA Information for Healthcare Professionals: Tacrolimus. Available at: http://www.fda.gov/Drugs/ DrugSafety/PostmarketDrugSafetyInformationforPatients andProviders/ucm126497.htm. Accessed: August 2, 2010.
  12. Chamlin SL, et al. J Am Acad Dermatol 47(2):198-208 (2002 Aug).
  13. Sugarman JL, et al. J Drugs Dermatol 8(12):1106-11 (2009 Dec).

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