Amevive® (Alefacept) - A - Detailing from Skin Therapy Letter


Amevive® (Alefacept)







  • Alefacept 15mg im. once per week
  • The standard treatment period is twelve, once-weekly injections, followed by a twelve week treatment-free period.
  • In trials, patients received weekly doses (12 weeks) of Alefacept or placebo and were monitored for an additional 12 weeks without treatment. A second 12 week course was initiated if it was determined that the patient would benefit from further clearing.
  • Clinical impressions have indicated that increasing the dosing period beyond 12 weeks (treat to clear) results in longer remissions
  • Patients should be administered at least two courses before deciding on next steps

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