Bactroban® (Mupirocin 2% Ointment and Cream) - A - Detailing from Skin Therapy Letter


Bactroban® (Mupirocin 2% Ointment and Cream)







  • Mupirocin 2% (Bactroban®, GlaxoSmithKline) is a topical antibacterial drug structurally unrelated to other agents and acts by inhibiting bacterial protein synthesis.
  • Clinical experience shows that this is a safe, effective and well-tolerated topical antibiotic available both in a cream and ointment.
  • It is very effective for localized impetigo as well as for skin lesions that have become secondarily infected with Staph or Strep, and is associated with fewer adverse effects than systemic antibiotic therapy.

Mechanism of Action

  • Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase.
  • Importantly, as a result, this product shows no cross-resistance with chloramphenicol, erythromycin, fusidic acid, gentamicin, lincomycin, methicillin, neomycin, novobiocin, penicillin, streptomycin and tetracycline.

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