Bactroban® (Mupirocin 2% Ointment and Cream) - A - Detailing from Skin Therapy Letter


Bactroban® (Mupirocin 2% Ointment and Cream)







  • Mupirocin 2% is indicated for the treatment of superficial skin infections caused by susceptible organisms.
  • Systemic anti-infective agents are generally required for treating serious, deep, or extensive skin infections.
    • Mupirocin has excellent activity against
    • S. aureus
    • S. epidermidis
    • S. pyogenes
    • and ß-hemolytic streptococci.


  • Impetigo
  • Secondary infection to skin trauma
  • Lacerations / Sutured wounds / Abrasions
  • Conditions that frequently have secondary infections
  • Eczema / Burns / Superficial ulcers
  • Nasal Staphylococcal Carriage
  • Clears S. aureus
  • Clears methicillin resistant S. aureus (MRSA) – Slide 6a
  • Clearance may not be permanent, so re-treatment is usually required

Intranasal mupriocin is effective for the elimination of staphylococci, even MRSA, from chronic carriers.


  • Mupirocin may be advantageous for topical treatment of staphylococcus-infected burns, especially those colonized with MRSA.
  • Experts recommend that mupirocin be used on burns encompassing less than 20% of body surface and for less than 5 days.

[Antimicrob Agents Chemother. 1989; 33:1358-61.]

Summary of Indications

Topical Cream: Secondarily infected traumatic skin lesions caused by susceptible strains of S. aureus and S. pyogenes.
Topical Ointment: Impetigo, superficially infected dermatoses and lesions that are moist and weeping caused by S. aureus, ß-hemolytic streptococcus and S. pyogenes.

Bactroban® Cream is as good as the ointment for treating the above indications and is cosmetically more acceptable.

[Compendium of Pharmaceuticals and Specialties, 36th Ed. Ottawa: Canadian Pharmacists’ Association (2001).]

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