Bactroban^® (Mupirocin 2% Ointment and Cream)

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INDICATIONS

• Mupirocin 2% is indicated for the treatment of superficial skin infections caused by susceptible organisms.
• Systemic anti-infective agents are generally required for treating serious, deep, or extensive skin infections.
• Mupirocin has excellent activity against
• S. aureus
• S. epidermidis
• S. pyogenes
• and ß-hemolytic streptococci.

Infections

• Impetigo
• Secondary infection to skin trauma
• Lacerations / Sutured wounds / Abrasions
• Conditions that frequently have secondary infections
• Eczema / Burns / Superficial ulcers
• Nasal Staphylococcal Carriage
• Clears S. aureus
• Clears methicillin resistant S. aureus (MRSA) – Slide 6a
• Clearance may not be permanent, so re-treatment is usually required

Intranasal mupriocin is effective for the elimination of staphylococci, even MRSA, from chronic carriers.

Burns

• Mupirocin may be advantageous for topical treatment of staphylococcus-infected burns, especially those colonized with MRSA.
• Experts recommend that mupirocin be used on burns encompassing less than 20% of body surface and for less than 5 days.

[Antimicrob Agents Chemother. 1989; 33:1358-61.]

Summary of Indications

Topical Cream: Secondarily infected traumatic skin lesions caused by susceptible strains of S. aureus and S. pyogenes.
Topical Ointment: Impetigo, superficially infected dermatoses and lesions that are moist and weeping caused by S. aureus, ß-hemolytic streptococcus and S. pyogenes.

Bactroban® Cream is as good as the ointment for treating the above indications and is cosmetically more acceptable.

[Compendium of Pharmaceuticals and Specialties, 36th Ed. Ottawa: Canadian Pharmacists’ Association (2001).]

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