- Mupirocin 2% is indicated for the treatment of superficial skin infections caused by susceptible organisms.
- Systemic anti-infective agents are generally required for treating serious, deep, or extensive skin infections.
- Mupirocin has excellent activity against
- S. aureus
- S. epidermidis
- S. pyogenes
- and ß-hemolytic streptococci.
- Secondary infection to skin trauma
- Lacerations / Sutured wounds / Abrasions
- Conditions that frequently have secondary infections
- Eczema / Burns / Superficial ulcers
- Nasal Staphylococcal Carriage
- Clears S. aureus
- Clears methicillin resistant S. aureus (MRSA) – Slide 6a
- Clearance may not be permanent, so re-treatment is usually required
Intranasal mupriocin is effective for the elimination of staphylococci, even MRSA, from chronic carriers.
- Mupirocin may be advantageous for topical treatment of staphylococcus-infected burns, especially those colonized with MRSA.
- Experts recommend that mupirocin be used on burns encompassing less than 20% of body surface and for less than 5 days.
[Antimicrob Agents Chemother. 1989; 33:1358-61.]
Summary of Indications
Topical Cream: Secondarily infected traumatic skin lesions caused by susceptible strains of S. aureus and S. pyogenes.
Topical Ointment: Impetigo, superficially infected dermatoses and lesions that are moist and weeping caused by S. aureus, ß-hemolytic streptococcus and S. pyogenes.
Bactroban® Cream is as good as the ointment for treating the above indications and is cosmetically more acceptable.
[Compendium of Pharmaceuticals and Specialties, 36th Ed. Ottawa: Canadian Pharmacists’ Association (2001).]