Clindoxyl® Gel (Clindamycin phosphate and benzoyl peroxide) - A - Detailing from Skin Therapy Letter


Clindoxyl® Gel (Clindamycin phosphate and benzoyl peroxide)







  • Clinical experience confirms what has been shown in clinical trials, that Clindoxyl Gel is effective and well tolerated
  • Once daily application of topical that combines two active anti-acne agents may well increase patient compliance
  • Clindoxyl Gel can be used once in the evening and a topical retinoid at an alternate time of day, if necessary

Mechanisms of action

  • Benzoyl peroxide - produces free-radical oxygen that oxidizes bacterial proteins and has a mild keratolytic effect on comedones
  • Clindamycin - inhibits bacterial protein synthesis by binding to 50S ribosomal units. It is bacteriostatic at low concentrations and bactericidal at higher concentrations.

Bacterial resistance

  • Antibiotic resistance to the follicular bacteria P. acnes has been increasing over the years of antibiotic use
  • Antibiotic resistant P. acnes increased from 34% in 1991 to 60% in 1996 in an acne outpatient clinic in Leeds in England
  • Resistance was most commonly seen to erythromycin. This suggests that erythromycin might be less suited for long term use.
  • Adding benzoyl peroxide to a topical antibiotic appears to reduce the ability of the bacteria to become resistant.

Next:   Indications