Cutivate® (Fluticasone propionate) - A - Detailing from Skin Therapy Letter

 

Cutivate® (Fluticasone propionate)

 

 

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INDICATIONS

 

 


  • Used for all inflammatory and pruritic conditions that are corticosteroid responsive e.g. eczema, psoriasis and dermatitis
  • It should not be used in rosacea, acne, or perioral dermatitis. It should be also avoided in viral infections such as herpes simplex and chicken pox, as well as in lesions infected with fungi.
  • Prolonged use on the face and folds needs to be avoided

Guidelines of Care for Atopic Dermatitis

  • “Topical steroids are the standard of care to which other treatments are to be compared”
  • “There are limited data regarding the optimal corticosteroid concentration, duration and frequency of application”
  • “Long –term intermittent application of corticosteroid appears safe and effective in two randomized controlled studies”
  • Topical corticosteroids first introduced in the 1950’s have been the mainstay of therapy of atopic dermatitis
  • “Emollients are a standard of care, steroid-sparing, and useful for both prevention and maintenance therapy”
  • Tacrolimus and pimecolimus has been shown to reduce the extent, severity and symptoms of AD in children and adults
  • Information is lacking as to the best way that these drugs can be combined with topical corticosteroids to maximise efficacy,minimise side-effects and reduce costs to the patient

Tachyphlaxis and Rebound

  • Tachyphlaxis (effectiveness diminishes progressively on continued therapy) and rebound (flare of disease worse than base line on stopping therapy) do not appear to be a problem with Fluticasone propionate
  • [J. Berth-Jones1, M. Herdman2, E Glazenburg3. on behalf of an International Study Group. 1Coventry, UK, 2GSK, R&D, UK, 1GSK, The Netherlands.]


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