Minocycline (Minocin®, Dynacin®, Vectrin®) - A - Detailing from Skin Therapy Letter


Minocycline (Minocin®, Dynacin®, Vectrin®)







  • Oral antibiotics have had a significant role in the treatment of inflammatory disease such as acne, rosacea, perioral dermatitis and others. Tetracycline has long been the first line antibiotic for acneform eruptions because of its efficacy and affordability although in inconvenience of divides doses on an empty stomach has compromised compliance in some. P. acnes resistance to Tetracycline and Erythromycin has meant looking elsewhere for an alternative antibiotic. Bacterial resistance to Minocycline has been much slower to develop.
  • Topical therapy should always be used in combination with oral antibiotics and the combination of benzoyl peroxide may reduce the ability of bacteria to become resistant.
  • Minocycline has shown itself to be effective, convenient and well tolerated for most. The incidence of serious side effects is rare. There is a trend away from using these drugs for a long time such as a minimum of six months and toward short courses that aim at stopping new inflammatory lesions and then maintain control with topical therapy which could be combined with oral contraceptives.
  • Minocycline and doxycycline are more expensive than tetracycline and erythromycin and for some this is an important consideration.
  • Proper selection and appropriate monitoring of patients has made this drug a first line antibiotic for many dermatologists.

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