Minocycline (Minocin®, Dynacin®, Vectrin®) - A - Detailing from Skin Therapy Letter

 

Minocycline (Minocin®, Dynacin®, Vectrin®)

 

 

  Content:

COMPLIANCE / PHARMACOKINETICS

 

 


  • All tetracyclines are broad-spectrum bacteriostatic agents. They are well absorbed, although oxytetracycline and tetracycline should not be taken with food. Minocycline as well as Doxycycline are absorbed almost as well on an empty as full stomach The topical formulations are delivered to the pilosebaceous apparatus and adjacent tissues. There is little absorption of the topical formulations. Minocycline is very lipid soluble and achieves good sebum penetration. Doxycycline and Minocycline are partially inactivated in the liver so liver disease is a relative contraindication. Most Tetracyclines are eliminated unchanged in the urine and the feces. The half life of the Tetracyclines are prolonged in renal failure except for Doxycycline
  • Daily or bid dosing significantly helps the patient take the drug especially since it can be taken with or without food.

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