Minocycline (Minocin®, Dynacin®, Vectrin®) - A - Detailing from Skin Therapy Letter


Minocycline (Minocin®, Dynacin®, Vectrin®)







Trade Names:

Minocin* Stiefel Canada Inc.
Dynacin* Medicis
Vectrin* Medicis

Dosage Forms:

  • Capsules: Minocycline 50 and 100mg (Minocin* Dynacin*)
  • Suspension: Minocycline 50mg (Minocin* Dynacin*)
  • Parenteral: Minocycline 100mg (Minocin IV*)

Acne vulgaris

  • Minocycline 50-100 mg po bid, tapered to 50 mg/d as acne improves
  • Most will show satisfactory improvement with 100mg a day
  • Aim should be the prevention of new inflammatory lesions
  • Use for 8-12 weeks only if good clinical response
  • Avoid long term usage to minimize side effects and to reduce the risk of bacterial resistance (Dermatology 2003; 206(1):37-53)


  • Minocycline50-100mg daily until no further new lesions
  • Try and maintain control after this by topical therapy alone
  • Periodic use such as Minocycline 100mg daily for 1 week per month may be required if topicals alone not sufficient to prevent new lesions

Perioral dermatitis

  • Minocycline 50-100mg for 1 month will clear most
  • Some may need a further 1-2 months for cure

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