Minocycline (Minocin®, Dynacin®, Vectrin®) - A - Detailing from Skin Therapy Letter


Minocycline (Minocin®, Dynacin®, Vectrin®)







  • Improvement in inflammatory lesion in acne is about a 20% reduction a month. It may take 1-2 months to see initial benefit. After 6 months there is an approximate 60-70% improvement in inflammatory acne counts. Studies over the last 20 years have shown that tetracycline, erythromycin, doxycycline and minocycline have about the same efficacy in acne. Bacterial resistance has lowered the efficacy in particular of both erythromycin and tetracycline where as this has been less of a problem to date with minocycline although it is on the rise.
  • In clinical practice efficacy is in part related to compliance which may be less problematic in clinical trials.

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