Penlac® (Ciclopirox) - A - Detailing from Skin Therapy Letter


Penlac® (Ciclopirox)







Ciclopirox is incorporated into a clear nail lacquer at an 8% concentration which is applied directly onto the nail plate.This transungual delivery system is unique allowing for prolonged nail contact time and the development of a concentration gradient across the nail plate to enhance nail plate penetration. The lacquer adheres the drug to the nail plate and the evaporation of the lacquer solvents increases the drug concentration to 34%. The lacquer base also reduces transplate water loss which enhances transport of the drug within the nail plate.

[Onychomycosis, Baran et al 1999]

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