Soriatane© (Acitretin) - A - Detailing from Skin Therapy Letter

 

Soriatane© (Acitretin)

 

 

  Content:

MONITORING

 

 

Blood Tests

  • Complete blood count with platelets, prior to therapy, monthly for the first 3 to 6 months, and then every 3 months

Liver Function

  • Liver enzymes (AST, ALT, alkaline phosphatase, bilirubin) should be checked prior to therapy, monthly for the first 3 to 6 months, and then every 3 months
  • If liver function tests become abnormal, discontinuation of the drug should be considered

Lipoproteins

  • Lipoproteins (triglycerides, total cholesterol, LDL and HDL cholesterol) should be checked prior to therapy, monthly for the first 3 to 6 months, and then every 3 months
  • If increased triglycerides or decreased HDL is found, dietary fat and alcohol should be restricted

Renal Function

  • Tests Check blood urea nitrogen and creatinine prior to therapy, monthly for the first 3 to 6 months, and then every 3 months
  • Optional urinalysis if patients have renal diseases, proteinuria, diabetes or hypertension

Pregnancy Test

  • Prior to therapy and monthly thereafter

Ophthalmologic Evaluation

  • May wish to consider baseline and yearly ophthalmologic evaluation if patient has a history of cataracts or retinotherapy or if the patient reports symptoms of pseudotumour cerebri, including headaches, blurred vision or nausea and vomiting

Bone X-rays

  • Consider baseline x-rays of wrists, ankles or thoracic spine (with yearly follow-up x-rays) if planning on long-term retinoid therapy

Bone Age Determination in Children

  • Evaluation should be done before therapy and yearly thereafter to assess epiphysical growth plates and evaluate the possibility of skeletal hyperostosis


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