Soriatane^© (Acitretin)

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INDICATIONS - Off-Label Uses

Darier's Disease

• Most effective when treating widespread hyperkeratotic forms of Darier’s disease
• Episodic use is prudent, particularly in months when a flare-up is expected
• Lower starting dose of 0.2-0.3 mg/kg/day may prevent the initial flare-up commonly seen with patients treated with retinoids

Lamellar ichthyosis

• Good response often seen at 0.5-1 mg/kg/day, with significant response seen during the first 2 months of therapy
• Maintenance dose can be reduced to 25 mg/day

Erythrokeratoderma variabilis

• Patients should be started at low doses with a gradual dosage increase to avoid a flare-up in the number of erosions or bullae

Lichen planus

• Therapy of 30 mg/day for 8 weeks showed remission or marked improvements in 64% of patients in a double-blind placebo-controlled study
• Most effective when combined with a systemic corticosteroid to control severe cases

Pityriasis rubra pilaris

• The use of acitretin has not been reported, although it is assumed that it is effective when given within a dose range of 1 mg/kg/day

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