Skin Therapy Letter HOME
Written for dermatologists by dermatologists. Indexed by the US National Library of Medicine.
Skin Information
NETWORK
Skin Therapy Letter About STL Subscribe Today SkinCareGuide Network Site Map
CUSTOM DERMATOLOGY SEARCH:
Loading

Clotrimazole

Azole: a broad spectrum antifungal developed in 1967. It was one of the first azoles to be developed. Formulations are now generic in a number of countries.
It is effective against Candida albicans and the dermatophytes. Its action is fungistatic or fungicidal, depending upon the concentration used.
This azole drug is available in a variety of dosage forms, including oral lozenges and vaginal formulations. It is also available in a variety of combinations with antibiotics and corticosteroids.

Trade Name:

  • Canesten* Bayer
  • Mycelex* Bayer
  • Desenex* Novartis

Oral:

  • Lozenges: Clotrimazole 10 mg Mycelex*
  • Topical: Cream: Clotrimazole 1% Desenex* Lotrimin*
            - Lotion: Clotrimazole 1% Desenex* Lotrimin*
            - Solution: Clotrimazole 1% Desenex*

Used for

  • Tinea corporis
  • Tinea cruris
  • Tinea pedis
  • Pityriasis versicolor
  • Cutaneous candidiasis
  • Nail and skin infections, fungal or gram positive

Therapeutic Regimen

Adult

Pediatric

Dermatomycoses

Clotrimazole 1% cream, solution, or lotion bid x14-28d, apply in a thin layer to the affected area and surrounding skin.

  • Topical preparations should not be used in children < 2 years old
  • Vaginal preparations are not recommended for children < 12 years old
  • Lozenges should not be used in children < 5 years old


Safety Information

  • Avoid applying dressings that seal the area
  • Elevated liver function tests have been observed in patients using Clotrimazole lozenges.

Side Effects

Local cutaneous effects may include irritation, hypersensitivity, burning, pruritus, erythema, fissuring, or swelling.

FDA Pregnancy Category C
Oral formulation shows toxicity in animal trials. Use is not recommended during pregnancy or lactation.

Mechanism of Action / Pharmacokinetics

Clotrimazole damages the fungal cell wall and alters the permeability. It also inhibits the activity of intracellular enzymes, leading to a buildup of toxic concentrations of hydrogen peroxide within the fungal cell, causing death of the cell. Systemic absorption is minimal.