Fluconazole is an antifungal azole. It is a broad spectrum antifungal, first approved in Europe in 1988 and then in America in 1990.
It was the first single dose treatment approved for vaginal candidiasis. Fluconazole is an effective agent in the treatment and prophylaxis of Candidal infection
- Diflucan* Roerig
- Diflucan* Pfizer
- Oral: Tablets: Fluconazole 50, 100, 150, 200mg Diflucan*
- Capsules: Fluconazole 150mg Diflucan*
- Suspension: Fluconazole for 10mg/mL or 40 mg/mL Diflucan
- Parenteral: Fluconazole 200mg/100mL and 400mg/200mL Diflucan*
- Candidiasis, vulvo-vaginalCandidiasis,
- Candidiasis, cutaneous #
- Tinea corporis #
- Tinea cruris #
- Tinea pedis #
# - not included in Canadian labeling
- Fluconazole capsules 150 mg po x1 dose
Tinea pedis, cruris, corporis, versicolor (off label)
- Fluconazole capsules 200 mg po x1, followed by 100mg po daily x 2 weeks
- Fluconazole capsules 50 mg po daily x2-6
|Dosage has not been established for infants < 6 months old |
> 6 months
- Fluconazole oral suspension 3mg/kg x2 weeks
Hepatic function tests should be monitored periodically during treatment. Transient increases in transaminases have rarely led to hepatotoxicity in patients receiving fluconazole.
Dose adjustment may be required in patients with renal function impairment.
FDA Pregnancy Category C
- Cutaneous effects may include hypersensitivity reactions including exfoliative dermatitis and Stevens-Johnson syndrome
- Gastrointestinal effects may include nausea, abdominal pain, diarrhea, constipation, loss of appetite and rarely, hepatotoxicity.
- Hematologic effects may include agranulocytosis or thrombocytopenia.
- Other effects may include headache, dizziness and drowsiness.
Animal studies report rare fetal abnormalities. Not recommended during pregnancy or lactation.
Major Drug Interactions
Concurrent use of antidiabetic agents can lead to hypoglycemia; cyclosporine and phenytoin plasma concentrations may be increased; anticoagulant effects may be increased.
Mechanism of Action / Pharmacokinetics
Fluconazole inhibits ergosterol synthesis in the cell wall of yeast and other fungi.
In Candida albicans, fluconazole may also inhibit the transformation of blastospores into the invasive mycelial form. Fluconazole is absorbed quickly after oral administration and is widely distributed
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