Does Diet Really Affect Acne?
A review of studies, reviewing association between a high-glycemic-load diet, hormonal mediators, and acne risk.
A Physician’s Guide to Treating Acne
Acne is among the most common dermatological conditions seen in primary care. In this article, we provide a guide to address a growing need by primary care physicians to have a logical and practical approach to treating various forms of acne.
A Clinician’s Guide to Treating Acne
In this article, we provide a guide to address a growing need by primary care physicians to have a logical and practical approach to treating various forms of acne.
Polycystic Ovary Syndrome and Acne
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women. This article will review the treatments for acne due to androgen excess in PCOS women.
Benzoyl Peroxide: Enhancing Antibiotic Efficacy in Acne Management
Benzoyl peroxide is one of the most widely used topical agents for acne. This article discusses the anti-inflammatory and comedolytic effects of benzoyl peroxide.
The New Canadian Guideline for Acne Treatment
Physicians will be particularly reassured if the suggested guidelines are supported by scientific evidence. This new Canadian clinical guideline for the treatment of acne was developed taking into account new data published up to March 2015, as well as expert opinion and clinical experience.
Antibiotic Resistance in Acne Treatment
Propionibacterium acnes (P. acnes) is an anaerobic bacteria implicated in the pathogenesis of acne. Current treatment guidelines offer strategies to limit the potential for resistance while achieving optimal outcome in the management of inflammatory and non-inflammatory acne.
The Treatment of Cystic Acne
Cystic acne is characterized by the formation of cysts enclosing a mixture of keratin and sebum in varying proportions. It is the most severe of the four main types of acne, which are comedonal, papular, pustular, and cystic. Identification and treatment options are discussed.
Advances in Understanding Atrophic Acne Scarring and the Role of Adapalene/Benzoyl Peroxide
There have been important advances in our understanding of acne scarring. Acne scars can resolve, and their evolution is determined by a balance between matrix repair and degradation. Timely, effective management of acne can minimize risk of subsequent acne scarring.
Adapalene 0.1% and Benzoyl Peroxide 2.5%: A Novel Combination for Treatment of Acne Vulgaris
Topical products commonly used to treat acne include retinoids and antimicrobials, due to their effects on different components of pathogenesis. Accordingly, a fixed combination of adapalene 0.1% and benzoyl peroxide (BPO) 2.5% was developed (Epiduo™, Galderma) and was approved by the US FDA for the treatment of acne.
Improving Bioavailability with a Novel Isotretinoin Formulation (Isotretinoin-Lidose)
Current practice guidelines recommend administration of oral isotretinoin with high-fat meals, which may pose issues with patient compliance. This article discusses Isotretinoin-Lidose (Epuris™), pharmacokinetics, bioavailability, and increased drug absorption rate, and how it may improve patient compliance.
Management of Recalcitrant Acne
Acne treatment success involves a comprehensive approach that addresses diagnostic confounders, appropriate therapeutic options and patient adherence. Ongoing education and counselling will assist in meeting patient expectations and establishing a favourable rapport that promotes adherence.
Psychosocial Impact of Acne Vulgaris: Evaluating the Evidence
This paper reviews current evidence presented by recent studies on the impact of acne on psychosocial health. Effective treatment of acne was accompanied by improvement in self-esteem, affect, obsessive-compulsiveness, shame, embarrassment, body image, social assertiveness and self-confidence.
Acne in the Post-Adolescent Patient
For the purposes of this article, the focus will be on the topical treatment of post-adolescent mild to moderate acne. A selection of over-the-counter and prescription based topical treatments are discussed below.
What’s New in Acne Treatment in Canada?
Acne vulgaris is the most common skin disorder affecting children and young adults in North America. This article discusses combination therapy, and simplifying treatment plans in order to increase patient adherence, which is often a critical problem in treating acne.
Systemic Antibiotic Therapy for Acne: A Review
Acne is a multifactorial disease of the pilosebaceous unit in the skin. Four contributing pathogenic factors need to be elucidated and include excess sebum production, follicular hyperkeratinization, colonization of the pilosebaceous unit by Propionibacterium acnes.
A Novel Topical Retinoid for Acne: Trifarotene 50 μg/g Cream
In two large randomized vehicle-controlled 12-week trials and in a 52-week open label study of moderate-to-severe acne at the face and trunk in subjects aged 9 years and older, trifarotene 50 μg/g cream demonstrated efficacy, safety, and cutaneous tolerability.
Tazarotene as Acne Treatment Option
Tazarotene is a designer retinoid. It is approved by Health Canada as a treatment for psoriasis, acne, and photodamage. This article discussed its indications, side-effects, use, and drug interactions.
Trifarotene: A New Topical Retinoid for the Treatment of Acne Vulgaris
A new topical retinoid, trifarotene, the first fourth-generation retinoid, is now available in Canada for the treatment of moderate facial and truncal acne.
Hormonal Treatment of Acne in Canada: Clinical Update and Case-Based Treatment Approaches
Evolving understanding of the role of hormones in acne, along with a growing body of data from clinical trials, calls for a reappraisal of the role of hormonal therapy for acne.
A Controversial Proposal: No More Antibiotics for Acne!
Administration of antibiotics, often for prolonged periods, has become the standard of care for acne. The authors provide current evidence to suggest that dermatologists should consider a departure from standard operating procedure by curtailing, if not discontinuing, the routine and regular use of antibiotics for acne.
Non-Surgical Treatment of Acne Scars
Acne scars are challenging to treat. This article discusses the non-surgical treatment options like topical treatments, chemical peels, skin fillers, cover-ups, and injectables.
Novel Topical Drug Delivery Systems and Their Potential Use in Acne Vulgaris
A vast spectrum of topical anti-acne agents has emerged in response to new insights that have been gained through the understanding of disease pathophysiology and the need for clinicians to adopt an individualized therapeutic approach.
Adjunctive Skin Care for Acne
Acne vulgaris (AV) is among the most common dermatological disorders seen by dermatologists. Emerging evidence suggests that acne is associated with epidermal barrier impairments, and this article reviews the role of moisturizing, sun protection, and patient specific skincare advice for acne patients.
Moisturizers and Cleansers in the Management of Skin Conditions Caused by Personal Protective Equipment and Frequent Handwashing
Routine moisturization with non-irritating, pH-adjusted, ceramide-based products and gentle cleansing with a pH-adjusted cleanser can treat the unique dermatological challenges posed by COVID-19.
Oral Contraceptives in the Treatment of Acne
Oral contraceptives (OCs) can reduce acne by lowering the production of adrenal and ovarian androgens, by inhibiting 5- alpha-reductase, which in turn, reduces the levels of dihydrotestosterone, and by stimulating sex hormone binding globulin (SHBG), thus reducing the levels of free testosterone.
Topical Clascoterone for Acne Vulgaris
Clascoterone 1% cream represents a novel and promising therapeutic agent in the management of acne vulgaris for individuals ≥12 years of age. Notably, this topical agent was not observed to have significant systemic effects seen with systemic anti-androgenic agents.
Erythromycin as Acne Treatment
Erythromycin is an antibiotic in the macrolide group and is used in acne treatment. This article provides a summary of erythromycin, including side-effects, uses, and potential drug interactions for both topical and oral indications.
Dapsone 5% Gel: A New Option in Topical Therapy for Acne
Dapsone 5% gel for the topical treatment for acne represents the first new anti-acne agent to gain North American regulatory approval in the past decade. Dapsone's utility is attributable to its anti-inflammatory and antimicrobial properties, with more prominent effects occurring in inflammatory lesions.
Newer Approaches in Topical Combination Therapy for Acne
Acne vulgaris is a common chronic inflammatory cutaneous disease involving the pilosebaceous unit. This article discusses the multifactorial nature of acne pathophysiology, therapeutics, and mechanism of action.
Clindoxyl® Gel For The Treatment Of Acne Vulgaris
Clindoxyl® Gel (Stiefel) is a combination of 1% clindamycin phosphate and 5% benzoyl peroxide in a gel vehicle that is well tolerated and more efficacious than either active agent alone or the vehicle in reducing lesion counts and improving global scores in patients with moderate acne.
A Review of Systemic Retinoid Therapy for Acne and Related Conditions
Oral isotretinoin, since its introduction more than 20 years ago, has been and still is the 'gold standard' in the treatment of acne and its variants. This is the only approach to acne with the possibility of a permanent “cure” or long term remission.
Topical Treatment for Acne: A Case Study
Since patient compliance is a concern, a great deal of attention must be given to the methods available to minimize the chance of irritation. In the opinion of the author, this may be the single most important factor influencing the success of topical therapy in acne.
The Use Of Low Dose Oral Contraceptives for the Management of Acne
There is compelling evidence that oral contraceptives (OCs) are effective in the management of mild-moderate acne vulgaris, as well as cumulative evidence that elevated levels of androgens in acne patients, relative to appropriate controls, are an underlying pathophysiological factor in acne.
Laser Management of Acne Scarring
Acne scarring is often challenging to manage. This article discusses various laser treatments that are helpful in addressing abnormal color and texture in order to improve the appearance of an acne scar as well as review the appropriate use and side-effects of these treatments.
New Developments in Hormonal Therapy for Acne
Oral contraceptives (OCs) are a valuable option for the treatment of women with acne. The use of OCs can be considered across the spectrum of acne disease severity in women. In Canada, three preparations are approved for mild-to-moderate acne, and a fourth is indicated for severe acne.
The Impact of Acne on Quality of Life
Optimal acne therapy must take into account not only acne type and severity, but also the impact of this skin disorder on the patient’s quality of life.
Treatment of Acne Scarring
Acne scarring is common but surprisingly difficult to treat. Scars can involve textural change in the superficial and deep dermis, and can also be associated with erythema, and less often, pigmentary change. In general, treatment of acne scarring is a multistep procedure.
Advances in Acne Management and Patient Adherence
Acne vulgaris is a multifactorial disease characterized by different types of lesions at various stages of development. Treatment options, such as light based therapy and systemic therapy, as well as CIS-Isotretinoin (Epuris™) that increases absorption are discussed as well as patient adherence.
Using Androgen Blockers for Acne Treatment
Anti-androgens are drugs that block the receptors which allow your body’s cells to absorb the male hormones. The indications of these drugs, side-effects, and contraindications are discussed in this article.