STL Index for: Adalimumab
Update on Drugs & Devices: March-April 2022
This update covers Adalimumab biosimilar - Yuflyma™ (Celltrion Healthcare), Adalimumab biosimilar - Simlandi™ (Alvotech/JAMP Pharma), Abrocitinib tablet - Cibinqo® (Pfizer), Upadacitinib tablet - Rinvoq® (AbbVie), Risankizumab-rzaa SC injection - Skyrizi® (AbbVie), and HA-based dermal filler - Juvéderm® Volbella® XC (AbbVie/ Allergan Aesthetics).
Janus Kinase and Tyrosine Kinase Inhibitors in Dermatology: A Review of Their Utilization, Safety Profile and Future Applications
Currently, JAK inhibitors are only FDA approved for dermatologic, rheumatologic, and hematologic conditions. Recent studies show the utility of JAK inhibitors in treating atopic dermatitis, psoriasis, psoriatic arthritis, vitiligo, and alopecia areata.
Update on Drugs & Devices: January-February 2022
Drug update covering: Adalimumab-adbm for SC use - Cyltezo®, Tralokinumab for SC use - Adtralza® (in Canada), Tralokinumab-ldrm for SC use - Adbry™ (in US), Melanoma vaccine for IV use - BNT111, Adalimumab-aqvh for SC use - Yusimry™, and more...
Psoriasis Education Tool for Patient-Physician Decision-Making About Biologics: A Pilot Study
Although biologics are well-studied, expertise regarding their use is often lacking. Many biologics have been added to the market in recent years with distinctive characteristics. This study was designed to create a tool to assist physicians involved in the care of patients with psoriasis undergoing biologic treatment.
Bimekizumab for Moderate-to-Severe Plaque Psoriasis
Bimekizumab is a novel treatment for moderate-to-severe plaque psoriasis that has shown promising efficacy and safety in clinical trials. By simultaneously targeting two components of the IL-17 pathway, IL-17A and IL-17F, the biologic can downregulate proinflammatory signaling and rapidly improve patients’ skin.
Skin Treatments Introduced in 2020
This index covers all new skin treatments introduced in Skin Therapy Letter Dermatology Edition articles in 2020.
Update on Drugs & Devices: September-October 2020
This update covers: Guselkumab SC use (Tremfya®), Adalimumab-fkjp SC use (Hulio®), Collagenase clostridium histolyticum-aaes SC use (Qwo™), Protein replacement therapy for XLHED (ER-004), Pembrolizumab IV use (Keytruda®), Minocycline 1.5% foam (Zilxi™), Microbiome-based non-aqueous ointment (ATR-12), Dupilumab SC use (Dupixent®) and Selumetinib capsules (Koselugo™)
Risankizumab, an IL-23p19 Inhibitor for Psoriasis: A Review of the Current Literature
The addition of biologics that target IL-23p19 (Risankizumab) to our therapeutic armamentarium has succeeded in improving outcomes in patients with moderate-to-severe plaque psoriasis.
Update on Drugs & Devices: January – February 2020
This update covers Lebrikizumab SC injection (Dermira), Infliximab-axxq for IV injection (Avsola™, Amgen), Trifarotene cream 50 mcg/g (Aklief®, Galderma), Adalimumab-afzb for SC injection (Abrilada™, Pfizer), Lidocaine + tetracaine (7%/7%) local anesthetic cream (Pliaglis®, Crescita Therapeutics), Maralixibat oral solution (Mirum Pharmaceuticals), Cetirizine hydrochloride for IV injection (Quzyttir™, TerSera Therapeutics) and Minocycline foam 4% (Amzeeq™, Foamix)
Update on Drugs & Devices: September – October 2019
The latest drug & device update covers: Adalimumab-bwwd for SC injection (Hadlima™), Apremilast tablets (Otezla®), Calcipotriene + betamethasone dipropionate (Enstilar® foam Taclonex® topical suspension), Bempegaldesleukin + nivolumab for IV use (NKTR-214 + Opdivo®), Dupilumab for SC injection (Dupixent®), Magnetic muscle stimulation for body contouring (CoolTone™), Laser device for body contouring (eon™ FR).
Skin Treatments Introduced in 2018
A list of skin treatments introduced in 2018, categorized by type/class of therapy. The content primarily focuses on approvals issued by US and Canadian drug regulatory agencies and is sourced from both regulatory and industry news releases.
Update on Drugs & Devices: January – February 2019
Update on Dalbavancin hydrochloride for IV infusion (Xydalba™), Omadacycline for IV and oral use (Nuzyra™), Tildrakizumab-asmn for SC injection (Ilumya™), Adalimumab-adaz for SC injection (Hyrimoz™) and other new drugs and treatments.
Skin Treatments Introduced in 2017
A look back at skin treatments introduced in 2017 for the following type/class of therapy: Antibiotic agents, anti-cancer agents, atopic dermatitis, dermal fillers, fabry disease, hereditary angioedema, herpes zoster, hidradenitis suppurativa, psoriasis, psoriatic arthritis, rosacea...
Update on Drugs and Drug News: November-December 2017
November-December 2017 Update on drugs includes Adalimumab-adbm for SC injection Cyltezo™, Adalimumab biosimilar Imraldi®, Cemiplimab REGN2810, Oral migalastat
Galafold™, and Secnidazole oral granules Solosec™
Hepatitis B and C Viruses and Biologics
Hepatitis B virus (HBV) and hepatitis C virus (HCV) potentially impact the clinician's ability to manage patients with immunosuppressive medications such as biological therapy. In light of recent literature reviews, patients with HBV and HCV should be referred to a hepatologist.
Update on Drugs and Drug News: May-June 2017
Update on Dupilumab for SC injection Dupixent®, Dupilumab for SC injection, Avelumab for IV injection Bavencio®, Hyaluronic acidbased injectable dermal filler Juvéderm®, Biosimilar to adalimumab for SC injection Amgevita™ Vollure™ XC, Adalimumab for SC injection Humira®, and Amgevita™.
Tofacitinib in the Treatment of Rheumatoid Arthritis and Chronic Plaque Psoriasis
Tofacitinib is an oral immunosuppressant approved for the treatment of rheumatoid arthritis (RA) and is currently undergoing investigation (Phase III trials) for treating chronic plaque psoriasis.
A Review of Guselkumab, an IL-23 Inhibitor, for Moderate-to-Severe Plaque Psoriasis
Psoriasis is thought to arise from a combination of pathogenic factors including genetic susceptibility and environmental exacerbation. This article reviews the current status of guselkumab as a therapy for moderate-to-severe plaque psoriasis.
Skin Treatments Introduced in 2016
The list covers new skin treatments for Actinic Keratosis, Hemangioma, Hidradenitis Suppurativa, as well as Anti-acne Agents, Antibacterial Agents, Anti-cancer Agents, Dermal Fillers, Neuromodulator and other treatments and drugs.
A Dermatologist’s Guide to Infection Screening Prior to Initiating Immunosuppressive Therapy
In this review, we summarize the most common immunosuppressant medications currently used in dermatology, and provide recommendations for infection screening prior to
initiating treatment.
Update on Drugs and Drug News: November-December 2016
Update on drugs, approval dates, and comments. Brodalumab for SC injection (Lumicef®), Etanercept-szzs for SC injection (Amjevita™), Propranolol hydrochloride oral solution 3.75 mg/ml (Hemangiol®), Calcipotriol 50 mcg/g + betamethasone dipropionate 0.5 mg/g foam (Enstilar®) are covered.
Adalimumab (Humira) for the Treatment of Hidradenitis Suppurativa
Adalimumab (Humira®) is a novel therapy approved by the US Food and Drug Administration, Health Canada, and the European Commission for the treatment of hidradenitis suppurativa (HS). Discussion includes, safety and efficacy in clinical trials.
Update on Drugs and Drug News: March-April 2016
Update on (Beteflam™), Human papillomavirus (HPV) 9-valent vaccine, recombinant (Gardasil®9), (Imlygic®), Pembrolizumab IV injection (Keytruda®), Adalimumab SC injection (Humira®), Secukinumab SC injection (Cosentyx®), Ustekinumab SC injection (Stelara®), and Nivolumab + ipilimumab (Opdivo® + Yervoy®).
Update on Drugs and Drug News: November-December 2015
Update on Polidocanol 1% injectable foam (Varithena®), Cobimetinib + vemurafenib (Cotellic™ + Zelboraf®), Adalimumab SC injection (Humira®), Hyaluronic acid filler (Juvederm® Ultra XC), Nivolumab + ipilimumab (Opdivo® + Yervoy®), Ingenol mebutate gel (Picato®)
Update on Drugs and Drug News: July-August 2015
Update on Deoxycholic acid injection (Kybella™), Ivermectin 1% cream (Rosiver®), Adalimumab SC injection (Humira®), Apremilast tablets (Otezla®), and Dermal filler with calcium hydroxylapatite (CaHA) (Radiesse®)
Hidradenitis Suppurativa: A Review with a Focus on Treatment Data
Hidradenitis suppurativa (HS) is a chronic disease of the follicular unit that often leads to marked impairment of quality of life. This article reviews various treatment modalities for HS including laser, surgery, retinoids, immunosuppression, biologics, and antibiotics.
Current Management of Scalp Psoriasis
The scalp is involved in up to 80% of individuals with psoriasis. Topical treatment with corticosteroids with or without vitamin D3 analogues is the mainstay of treatment, but other therapies such as light treatment and systemic drugs including biologics are discussed.
Interleukin-23 in the Pathogenesis and Treatment of Psoriasis
In the past three decades, major advances have been made in understanding the pathogenesis of psoriasis. This review focuses on the role of IL-23 in psoriasis pathogenesis and the current therapies targeting IL-23 that are being studied in clinical trials.
The Evolving Role of Biologics in the Treatment of Pediatric Psoriasis
The exact role of biologics in the treatment of pediatric psoriasis remains undefined but evolving. This article will provide a summary of the cumulative pediatric safety and efficacy data for the anti-tumor necrosis factor-alpha (TNF-α) agents and interleukin (IL)-12 and IL-23 (IL12/23) pathway inhibitor.
Biologic Therapy and Risk of Infection
Biologic compounds are being used more frequently to treat a multitude of systemic inflammatory conditions. This article discusses the increased risk of opportunistic infections of tuberculosis, herpes zoster, Legionella pneumophila, and Listeria monocytogenes.
Combination Therapy of Biologics with Traditional Agents in Psoriasis
Biologics plays an important role in treating moderate to severe psoriasis. This article looks at combination treatment with traditional systemics and topicals, and the possible benefits of this approach.
Drug Treatments for Skin Disease Introduced in 2010
An overview and update of skin conditions and treatments introduced in 2010: Quick overview of drug name, indications and regulatory status. Adapalene 0.1% lotion (Differin®), Clindamycin phosphate 1.2% + tretinoin 0.025% gel (Veltin™) and many other drugs are covered.
Drug Treatments for Skin Disease Introduced in 2010
Drug Treatments for Skin Disease Introduced in 2010. Adapalene 0.1% lotion (Differin®), Drospirenone / ethinyl estradiol / levomefolate calcium + levomefolate calcium tablets (Beyaz™) and many other drugs are covered.
Drug Treatments for Skin Disease Introduced in 2007
Treatments introduced in 2007 including Adapalene Gel 0.3% Differin®, Drospirenone/ Ethinyl Estradiol Yaz®, Tretinoin 0.05% Gel Anthralin®, Daptomycin for Injection CUBICIN®, Retapamulin Ointment 1% Altabax®, Tinidazole Tablets Tindamax® and other treatments.
TNF-a Inhibitors in Dermatology
To date, the US FDA has approved three tumor necrosis factor (TNF)-a inhibitors for use in dermatology. The distinct and targeted mechanism of action of the TNF inhibitors allows dermatologists to customize therapy to match the individual needs and characteristics of patients who are candidates for systemic therapy.
Drug Treatments for Skin Disease Introduced in 2006
An overview and update of skin conditions and treatments introduced in 2006: Quick overview of drug name, indications and regulatory status
A Review of Biologic Treatments for Psoriasis with Emphasis on Infliximab
Moderate-to-severe psoriasis is known to affect millions of people around the globe. This chronic disease substantially impacts patients by impairing their quality of life. The biologics are the newest and most effective therapeutic weapon in the treatment of moderate-to-severe psoriasis and psoriatic arthritis.