STL Index for: Santina Conte

The skin has long been read as a mirror of internal disease, but its relationship with bone is less familiar. Dermis and bone share a common embryonic origin, overlapping cell lineages, and collagen as a structural backbone. This review examines the skin-bone axis — vitamin D signalling, cystatin A, inflammatory dermatoses, corticosteroid effects on bone, cutaneous signs of metabolic and autoinflammatory bone disease, and the gut microbiome's role in both — and makes the case for a multidisciplinary approach to healthy aging.

Skin aging, caused by a combination of intrinsic and extrinsic factors, leads to decreased collagen, elastin and hydration levels with subsequent volume loss, dullness, uneven skin tone and fine lines, among other undesirable features. Individuals, especially youth, have become increasingly interested in slowing or preventing the aging process, given the impact of skin appearance on one’s self-esteem, social interactions and overall quality of life...

Discover how trifarotene, a fourth-generation retinoid, effectively treats acne and post-inflammatory hyperpigmentation (PIH). Learn about its benefits, clinical evidence, and role in managing acne sequelae.

Review of the effectiveness of trifarotene, a novel retinoid, in managing atrophic acne scars, highlighting its targeted action on retinoid acid receptor gamma (RAR-γ) and presenting recent clinical data supporting its use as a valuable adjunct treatment for acne scarring.