STL Index for: Prajapati V.

The pemphigus variants represent a group of potentially life-threatening autoimmune mucocutaneous blistering diseases. Herein, we focus on the new and emerging therapies in the management of pemphigus.

Rituximab (Rituxan®, Genentech/ Biogen Idec) is a genetically engineered chimeric murine/human monoclonal antibody directed against CD20. While anecdotal case reports recommend its “off-label” use in dermatology, randomized clinical trials are required to firmly establish the safety and efficacy.