Fat grafting, the transplantation of fat cells from one site to another to restore volume where volume is lost, has an added rejuvenating benefit.
Grafted fat is transferred as whole cells which are believed to contain stem cells that release cytokines and growth factors. This promotes a rejuvenative process in the surrounding skin, and studies have shown that there is an increase in collagen production in the dermis where fat has been grafted. This improves the quality of the overlying skin as an additional benefit to volume restoration.