Dermal Fillers: Ever-Expanding Options For Esthetic Use

Aesthetic volume rejuvenation with dermal fillers continues to be a popular procedure that is sought by a growing number of patients who seek the rounder softer contours attributable to a more youthful appearance. This article will focus on the most popular, time tested, and innovative fillers available today.

Update on Drugs and Drug News: January-February 2015

Update on Apremilast tablets (Otezla®), Collagenase clostridium histolyticum for injection (Xiaflex®), Afamelanotide 16 mg subcutaneous bioresorbable implants (Scenesse®), Clindamycin phosphate 1.2% + benzoyl peroxide 3.75% gel (Onexton™), Dupilumab SC injection, Apremilast tablets (Otezla®).

The Skin-Cap® Story

A review of the history surrounding the Skin-Cap controversy as it unfolded.

Frontal Fibrosing Alopecia

Frontal fibrosing alopecia has become one of the most frequently seen causes of scarring alopecia at many specialist hair clinics. It has distinctive features and associations which distinguish it from LPP. Discussion includes familial or genetic factors, etiology, and trials.

Update on Drugs and Drug News: June 2012

Update on Taliglucerase alfa for injection (Elelyso™ Differin®) as well as devices like Nd:YAG surgical laser (Fotona® XP Laser), Q-switched laser for melasma (Spectra™), Diode hair removal laser (Advantage™), Low-level laser diode device for circumferential reduction (i-Lipo™), Multiwavelength diode laser (Evolve® HPD)

Combining Chin-Jowl Implants With Local Anesthesia Facial Rejuvenation

Mandibular implantation is an outpatient procedure that can be used in combination with other minimally invasive cosmetic interventions. Specifically, silastic chin implants can help create a strong chin and smooth the jawline in carefully selected patients.

Update on Drugs and Drug News: March-April 2013

Update on Ingenol mebutate gel (0.015%, 0.05%) Picato™, Adapalene 0.1% + benzoyl peroxide 2.5% gel (Epiduo®), and Hydrogel for skin and wound care (Vashe® Skin and Wound Hydrogel)

Ciclopirox Shampoo for Treating Seborrheic Dermatitis

Seborrheic dermatitis is a common inflammatory skin disease, affecting between 1% and 3% of immunocompetent adults. While its cause is unknown, a number of predisposing factors have been reported, including the implications of Malassezia yeasts.

Skin, Hair and Nail Supplements: An Evidence-Based Approach

Dermatology supplements, often marketed as “skin, hair, and nail” supplements, are becoming increasingly popular. However, many consumers lack an understanding of the science of dietary supplements or the specifics of the supplement industry.

A Review of Guselkumab, an IL-23 Inhibitor, for Moderate-to-Severe Plaque Psoriasis

Psoriasis is thought to arise from a combination of pathogenic factors including genetic susceptibility and environmental exacerbation. This article reviews the current status of guselkumab as a therapy for moderate-to-severe plaque psoriasis.

Update on Drugs and Drug News: April 2010

Update on drugs, approval dates, and comments. Collagenase clostridium histolyticum (XIAFLEX™), HPV quadrivalent recombinant vaccine (Gardasil®), Velaglucerase alfa (VPRIV™), Agalsidase alfa (REPLAGAL®), Adalimumab (Humira®) are covered.

Vitamin B Derivative (Nicotinamide) Appears to Reduce Skin Cancer Risk

Recent studies have demonstrated the role of Vitamin B Derivative (Nicotinamide), in both topical and oral forms, as a chemopreventive agent against skin cancer.

The Use of Lasers in the Pediatric Population

Over the past 2 decades, there have been numerous advances in laser therapy of birthmarks in the pediatric population. Concerns regarding efficacy, overall benefit, and side-effects linger.

Update on Drugs and Drug News: May, 2000

Update on: Bexarotene Capsules Targretin Temozolomide Temodal Mequinol 2%/Tretinoin 0.01% Solage Linezolid Zyvox Amphotericin B Liposome for Injection Ambisome Terbinafine HCl 1% Solution Lamisil

Update on Drugs & Drug News October 2005

Updates on: Tigecycline Tygacil™ Terbinafine HCl Lamisil® Tablets Moxifloxacin HCl Avelox® Adalimumab Humira®

Real-World Efficacy of Azelaic Acid 15% Gel for the Reduction of Inflammatory Lesions of Rosacea

Use of azelaic acid was associated with a significant reduction in inflammatory lesions, which persisted beyond the active treatment phase. Overall, azelaic acid 15% gel is an appropriate initial topical therapy for the treatment of moderate facial rosacea.

Update on Drugs & Devices: May – June 2020

Update on Selumetinib capsules (Koselugo®), Crisaborole 2% ointment (Eucrisa®), Infliximab biosimilar for IV injection (Avsola™) and Baricitinib tablets (Olumiant®)

Update on Immunotherapeutics in the Management of Metastatic Melanoma

There are many new immunotherapeutics that have been approved or are in clinical and pre-clinical trials to expand our arsenal in the treatment of melanoma and other previously difficult to treat malignancies.

An Overview of Parabens and Allergic Contact Dermatitis

Parabens have been under scrutiny for some time with the very limited reports of paraben-induced allergic contact dermatitis. This article discusses the controversy, the data, and how the facts may not match up with the concern.

Skin Treatments Introduced in 2014

An overview and update of skin treatments introduced in 2014: Quick overview of drug name, indications and regulatory status. Clindamycin phosphate 1.2% + benzoyl peroxide 3.75% gel (Onexton™), Doxycycline hyclate tablets (Acticlate™), Tretinoin gel microsphere 0.08% (Retin-A Micro®) and many other drugs are covered.

Nicotinamide: An Update and Review of Safety & Differences from Niacin

Oral nicotinamide is an affordable over-the-counter supplement with demonstrated benefit in the treatment of a range of skin conditions, most notably AK and NMSC.

Oral Lichen Planus: Treatment Options

Estimates of the percentage of patients with cutaneous lichen planus (LP) who also have oral LP vary from somewhere between a third and a half 1-3, to as high as 70% and even higher when the cutaneous lesions are of long duration.

Concepts in a Multiprong Approach to Photoaging

Photoaging is a multisystem degenerative process that involves the skin and the skin support systems, including the bone, cartilage, and subcutaneous compartments. These structures provide the architectural support for the dermis, epidermis, and stratum corneum.

Vulvovaginal Dryness and Itching

Dryness and itching in the vulvovaginal area is an increasing problem as our female population ages and becomes menopausal. This dryness and itching is often the result of estrogen deficiency, and there are typically two types of treatment: Specific Therapy (or hormone replacement therapy), and Nonspecific Therapy.

Efinaconazole: A New Topical Treatment for Onychomycosis

Nail fungus, left untreated, the infection can spread to other nails and potentially cause further complications. This article reviews efinaconazole 10% as a topical monotherapy. Clinical trial data, mechanism of action, and future treatments are discussed.

Crisaborole 2% Ointment for Mild-to-Moderate Atopic Dermatitis

Crisaborole provides a novel and safe treatment option for mild-to-moderate AD.

Update on Drugs and Drug News: November 2002

Updates on: Cetirizine HCl Zyrtec®Pimecrolimus Elidel® Cream Imiquimod Aldara® Cream Valacyclovir HCl Valtrex®

Rosacea: Update on Management and Emerging Therapies

Rosacea is a common chronic skin disorder that has significant impact on the quality of life of affected individuals. Research interest has led to the development of other emerging therapies including topical ivermectin, brimonidine and oxymetazoline that hold promise for patients suffering from this condition.

Update on Drugs and Drug News: January, 1999

Update on: Lidocaine 2.5%, prilocaine 2.5% Emla® patch Cyclosporin SangCya®Metronidazole lotion 0.75% Metrolotion® Imiquimod Aldara® 2-octylcyanoacrylate Dermabond Topical Skin Adhesive®Alitretinoin gel 0.1% Panretin®Loratidine Claritin®Cetirizine Zyrtec®Penciclovir Denavir®Lyme disease vaccine LYMErix®

Body Piercing: More Than Skin Deep

Young adult populations (18-25 years of age) throughout the world have latched onto the mainstream trend of body piercing. Best health care practices for these individuals involves the knowledge of proper procedural techniques, postsite care, common complications, and treatment modalities.

Update on Drugs and Drug News: November 2001

Update on: Etanercept Enbrel® Clindamycin 1%, Benzoyl Peroxide 5% BenzaClin™ Ethinylestradiol & Norethindrone Acetate Estrostep Desloratadine Aerius™ & Neoclarityn™ Agalsidase Alfa Replagal™ Ciprofloxacin Butenafine HCl Mentax®

Systemic Therapy for Rosacea

Rosacea is a common condition that affects people of all races. More aggressive and innovative uses of existing oral agents have resulted in novel therapeutic approaches, which can provide long-term therapy and sustained remission.

Update on Drugs and Drug News: November-December 2012

Update on drugs, approval dates, and comments. Poly-ureaurethane 16% nail solution (Nuvail™), Calcipotriene 0.005% foam (Sorilux™), Hyaluronic acid injectable gel (Restylane-L®) are covered.

The Use of Alefacept in the Treatment of Psoriasis

Alefacept (AMEVIVE™ or LFA3TIP, Biogen) is the newest systemic therapy for chronic plaque psoriasis and was approved by the US FDA in January 2003. Clinical studies have shown that alefacept, given via weekly IM or IV injections for 12 weeks, was well tolerated, with no reported serious adverse events.

New Developments in Topical Sequential Therapy for Psoriasis

Topical agents for the treatment of psoriasis are indicated for patients whose affected area is < 10% of their skin. However, for long-term use, their effectiveness can be limited. Topical sequential therapy involves the application of a class I corticosteroid and calcipotriene in three different phases.

The A-B-C-Ds of Sensible Sun Protection

Ultraviolet (UV) radiation is a carcinogen that also compromises skin appearance and function. Since the UV action spectra for DNA damage, skin cancer, and vitamin D photosynthesis are identical, and vitamin D is readily available from oral supplements, why has sun protection become controversial?

Dermatitis Herpetiformis

Dermatitis herpetiformis is an autoimmune, pleiomorphic, papulovesicular disorder associated with celiac disease and gluten sensitivity. This article will provide a comprehensive review of Dermatitis herpetiformis, including its epidemiology, clinical and pathological findings, diagnostic evaluation, and management.

Topical Antipsoriatics

With growing public reluctance to use systemic medications we can expect topical treatments for psoriasis and other skin conditions to become increasingly important in the future. These drugs are useful not only to control this disease, but also to limit the irritation caused by medications such as tazarotene and anthralin.

Imiquimod: An Immune Response Modifier

Imiquimod is an immune response modifier. Studies have shown that it has potent immunomodulatory effects and stimulates human peripheral mononuclear cells to release interferon alpha, sub-types α1,α2, α5, α6, and α8.

Novel Dermatologic Uses of the Immune Response Modifier Imiquimod 5% Cream

Imiquimod is the first of a new class of drugs to emerge in the treatment of various dermatologic disorders. As an immune response modifier, it has been shown to have potent antiviral and antitumor properties through the stimulation of innate and cell mediated immune pathways.

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