The Use Of Interleukins For Advanced Melanoma

Treatment of metastatic melanoma using traditional chemotherapy regimens has been disappointing. However, recent work with agents that modify the host’s immune system (e.g., interleukins) have provided limited but encouraging results. Interleukins are a group of molecules involved in immune cell signaling.

Update on Drugs and Drug News: July – August 2009

Update on Benzyl Alcohol Lotion 5% Sciele Pharma, Red Light Technology Device + Methyl Aminolevulinate Cream Aktilite® CL 128 + Metvix®, and news Nexavar®.

Topical Metronidazole for Rosacea

Rosacea is relatively common, typically occurring in individuals of Northern European and Celtic origin between 30 and 50 years of age. It is more common in women, but may be more severe in men. Currently there is no cure available for rosacea, but it can be controlled with topical and oral drug therapy.

Efficacy of Lasers and PDT for the Treatment of Acne Vulgaris

Acne vulgaris can represent a therapeutic challenge in terms of managing ongoing symptoms and preventing scar formation. Dermatologists may now have viable new alternatives for treating all grades of acne severity that circumvent the negative side-effects associated with many conventional options.

Antidepressant Drugs in Dermatology

Antidepressant drugs can be an important component of the dermatologist’s armamentarium. Specific guidelines, side effect profile, drug-drug interactions, and the current indications should always be obtained for any particular antidepressant agent before it is prescribed.

Topical Treatment of Psoriasis in Children

Psoriasis is a common dermatosis, affecting children in North America. Many papers have stressed the treatments available for adult psoriasis, but few have dealt with this disorder in children. Topical treatment modalities continue to be the first line therapy for childhood psoriasis.

The Role of Skin Care in Oncology Patients

The consensus paper aims to identify the impact on patients of skin toxicities associated with cancer treatment and evidence-based best practices for skincare to minimize or prevent these changes.

Treatment of Photoaging with Topical Aminolevulinic Acid and Light

Photodynamic therapy has been used for several years for the treatment of actinic keratoses and prevention of invasive nonmelanoma cancers. Recently, increasing physician expertise with the topical sensitizers and light sources employed in PDT has led to expanded applications.

Itraconazole (Sporanox®) for Seborrheic Dermatitis

Seborrheic dermatitis is a common superficial dermatosis, characterized by red, flaking areas of the skin, which may in some cases be covered with yellowish flakes. The most commonly affected areas are the nasolabial folds, ears, eyebrows, scalp and chest.

Frontal Fibrosing Alopecia

Frontal fibrosing alopecia has become one of the most frequently seen causes of scarring alopecia at many specialist hair clinics. It has distinctive features and associations which distinguish it from LPP. Discussion includes familial or genetic factors, etiology, and trials.

Penciclovir Cream – A New Treatment for Herpes Labialis

Penciclovir cream (Vectavir™/Denavir™, SmithKline Beecham) is a novel product, approved in 15 countries including the USA and UK, for the treatment of herpes simplex labialis in immunocompetent adults.

Etanercept for the Treatment of Psoriasis

Etanercept has recently been approved for the treatment of moderate-to-severe plaque psoriasis at a dose of 50mg twice per week for 12 weeks followed by a maintenance dose of 50mg once weekly thereafter. Clinical studies have shown excellent efficacy and a good safety profile in patients with psoriasis.

Practical Management Strategies for Diaper Dermatitis

Common diaper dermatitis is an irritant contact diaper dermatitis (IDD) created by the combined influence of moisture, warmth, urine, feces, friction, and secondary infection. This article will focus on practical management strategies for IDD.

Elective Treatment of Dermatosis Papulosa Nigra: A Review of Treatment Modalities

Dermatosis papulosa nigra is a benign skin lesion found most frequently on the face of patients with skin of color. This article compares treatment modalities for DPN.

Unanswered Questions in Antifungal Therapy for Onychomycosis

Onychomycosis has a significant impact on the patient. With three new, orally effective, antifungal agents, we have for the first time effective treatment that can provide benefit for a high percentage of patients. This review examines some of the areas of uncertainty and controversy.

The Role of Skin Care in Optimizing Treatment of Acne and Rosacea

A triad approach to the treatment of acne and rosacea has been recommended. This integrated management approach includes patient education, selection of therapeutic agents, and initiation of an appropriate skin care regime. Appropriate skin care recommendations for patients with acne and rosacea will be discussed.

Metastatic Melanoma: Optimizing Outcomes by Managing Dermatologic Toxicities Associated with Novel Therapies

The last couple of years have seen the beginning of a new era in the treatment of metastatic melanoma. This article focuses on BRAF inhibitors and immune modulators which have demonstrated an overall survival benefit, and the importance of limiting adverse events.

Labeling Laws for Personal Care Products: Potential Pitfalls for The Consumer

Consumers of personal care products must be made aware of the potential pitfalls that arise from current labeling practices and regulations. For example, terms such as “hypoallergenic“, “sensitive skin“, and ...

Update on Drugs and Drug News – February 2006

Update on Doxycycline Oracea® CollaGenex, Hydrogel Dressing MimyX™ Cream Stiefel Laboratories, and Aluma™ Skin Renewal System with FACES™ Lumenis.

Skin Treatments Introduced in 2020

This index covers all new skin treatments introduced in Skin Therapy Letter Dermatology Edition articles in 2020.

Update on Drugs and Drug News: September 2008

Update on Certolizumab pegol Cimzia® UCB S.A., Golimumab Centocor, Ceftobiprole medocaril ZEFTERA® Basilea Pharmaceuticals, and Tipranavir Aptivus® Boehringer-Ingelheim.

Update on Drugs and Drug News: April 2000

Update on: Estradiol Vaginal Ring Estring Allegra Piperonyl Butoxide/ Pyrethrins Rid Mousse Temoporfin Foscan

Treatment of Hyperhidrosis with Botulinum Toxin A

Focal hyperhidrosis of axillae, palms or soles is a frequent, socially debilitating condition, triggered by various emotional stimuli. There are several treatment options such as local application of metal salts or tap water iontophoresis, which provide temporary relief for patients.

Topical Tazarotene Therapy for Psoriasis, Acne Vulgaris, and Photoaging

Psoriasis, acne vulgaris and photoaging are common conditions. Tazarotene is a pro-drug of tazarotenic acid, a receptor-selective retinoid, which has shown efficacy in the treatment of these disorders. In the treatment of acne vulgaris, it has greater comedolytic activity than the currently available topical retinoids.

Drug Treatments for Skin Disease Introduced in 2008

An overview and update of skin conditions and treatments introduced in 2008 including Methyl Aminolevulinate HCl Cream Metvixia™ + Aktilite®, Adapalene 0.1% Differin® Gel, Clindamycin Phosphate 1.2% + Benzoyl Peroxide 2.5% Acanya® Gel, Ceftobiprole Medocaril IV ZEFTERA® and other treatments

Current Management of Actinic Keratoses

An actinic keratosis is a pre-malignant cutaneous lesion that frequently manifests in sun-exposed areas of the skin as a small, rough, scaly erythematous papule. Therapy choices are guided by efficacy, adverse effects, cosmetic results, and patient compliance.

Update on Drugs and Drug News – June 2008

Update on Calcipotriene 0.005% + Betamethasone Dipropionate 0.064% Topical Suspension (Taclonex Scalp®), Calcipotriene 0.005% Topical Solution, and Botulinum Toxin Type A (Reloxin®) and news about new drugs for acne and psoriasis.

Adalimumab (Humira) for the Treatment of Hidradenitis Suppurativa

Adalimumab (Humira®) is a novel therapy approved by the US Food and Drug Administration, Health Canada, and the European Commission for the treatment of hidradenitis suppurativa (HS). Discussion includes, safety and efficacy in clinical trials.

Concepts in a Multiprong Approach to Photoaging

Photoaging is a multisystem degenerative process that involves the skin and the skin support systems, including the bone, cartilage, and subcutaneous compartments. These structures provide the architectural support for the dermis, epidermis, and stratum corneum.

Update on Drugs & Devices: March-April 2022

This update covers Adalimumab biosimilar - Yuflyma™ (Celltrion Healthcare), Adalimumab biosimilar - Simlandi™ (Alvotech/JAMP Pharma), Abrocitinib tablet - Cibinqo® (Pfizer), Upadacitinib tablet - Rinvoq® (AbbVie), Risankizumab-rzaa SC injection - Skyrizi® (AbbVie), and HA-based dermal filler - Juvéderm® Volbella® XC (AbbVie/ Allergan Aesthetics).

Chemotherapy-Induced Hair Loss

Chemotherapy-induced hair loss occurs with an estimated incidence of 65%. This article discusses hair loss, topical minoxidil, scalp cooling and chemotherapy induced hair loss.

Tirbanibulin for the Treatment of Actinic Keratosis: A Review

Tirbanibulin effectively and completely cleared AK lesions with a 5-day application period while demonstrating a favorable safety profile, mild AEs, improved tolerability, and long-term results, making it a promising field therapy for AKs.

Update on Drugs and Drug News: February 2010

Update on Imiquimod 3.75% Cream Zyclara™, Acyclovir + Hydrocortisone Cream Xerclear®/Lipsovir®, as well as drug news on Titanium dioxide (TiO2).

The Impact of Acne on Quality of Life

Optimal acne therapy must take into account not only acne type and severity, but also the impact of this skin disorder on the patient’s quality of life.

Update on Drugs and Drug News: September-October 2014

Update on Tedizolid phosphate tablets and IV injection (Sivextro™), Hyaluronic acidbased dermal filler (Restylane® Silk), Trifarotene, Icatibant SC injection (Firazyr®), C1 esterase inhibitor (Ruconest®), Methotrexate SC injection (Rasuvo™), Tavaborole 5% topical solution (Kerydin™), Nivolumab IV infusion (Opdivo®), Doxycycline hyclate tablets (Acticlate™)

Sunscreens in the Management of Photodermatoses

Key to the management of photodermatoses is photoprotection, which includes seeking shade; wearing wide brimmed hats, and sunglasses; and applying sunscreens. This article discusses sunscreens, sun protection, UVA, UVB, and its role in managing various skin conditions.

The Utility of Patch Testing Children with Atopic Dermatitis

Allergic contact dermatitis (ACD) is more frequent in the pediatric population and in children with atopic dermatitis (AD) than has hitherto been appreciated. Patch testing, which is mediated by different immune mechanisms than prick skin testing, is both safe and diagnostically useful for individuals with AD.

Update on Drugs and Drug News: July 2012

Update on drugs, approval dates, and comments. CIP-Isotretinoin (Absorica™), Tazarotene 0.1% foam (Fabior™), Butoconazole nitrate 2% vaginal cream, Multisource radiofrequency aesthetic device (Glow by EndyMed™), Low-level laser for circumferential upper arm reduction (Zerona®) are covered.

Propylene Glycol: An Often Unrecognized Cause of Allergic Contact Dermatitis in Patients Using Topical Corticosteroids

Propylene glycol (PG) is considered to be a ubiquitous formulary ingredient used in many personal care products and pharmaceutical preparations. This review guides clinicians in selecting suitable topical corticosteroids.

Calcipotriol and Betamethasone Dipropionate (Dovobet®, Daivobet®): A New Formulation for the Treatment of Psoriasis

A new compound product containing calcipotriol 50μg/gm and betamethasone dipropionate 0.5mg/gm (Dovobet*, LEO Pharma) in an ointment base was recently introduced in Canada for the treatment of psoriasis.

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