Off-label (unlabeled) Use of Drugs

Some of the most striking advances in dermatology have followed the off-label use of drugs. This review examines some of the issues surrounding off-label use of drugs by dermatologists, illustrates the need for such use and looks at possible changes in the regulatory system.

Moisturizers: What They Are And How They Work

Moisturizers are widely used in various dermatologic and cosmetic skin therapies. Different classes of moisturizers are based on their mechanism of action, including occlusives, humectants, emollients and protein rejuvenators.

Update on Drugs and Drug News: July-August 2013

Update on Dabrafenib mesilate capsule (Tafinlar®), Trametinib dimethyl sulfoxide tablet (Mekinist™), and Vismodegib capsule (Erivedge®)

Update on Drugs and Drug News – February 2007

Update on Clindamycin Phosphate 1.2%/ Tretinoin 0.025% Ziana™ Gel, Adalimumab Humira®, Aminolevulinic Acid/ Light Levulan® Kerastick®, Oblimersen Sodium Injection Genasense™, and Epratuzumab LymphoCide™.

Pigmentary Disorders in Asian Skin: Treatment With Laser and Intense Pulsed Light Sources

The development of selective photothermolysis has enabled removal of targets such as melanin. Both lasers and intense pulsed light (IPL) sources have been used in the treatment of pigmented lesions, however careful selection is important to ensure success.

Update on Drugs and Drug News: September-October 2013

Update on Dabrafenib mesilate capsule (Tafinlar™), Trametinib dimethyl sulfoxide tablet (Mekinist™), and Vismodegib capsule (Erivedge®)

Labeling Laws for Personal Care Products: Potential Pitfalls for The Consumer

Consumers of personal care products must be made aware of the potential pitfalls that arise from current labeling practices and regulations. For example, terms such as “hypoallergenic“, “sensitive skin“, and ...

Cutaneous Reactions to Anticancer Agents Targeting the Epidermal Growth Factor Receptor: A Dermatology-Oncology Perspective

The epidermal growth factor receptor (EGFR) is often overexpressed or dysregulated in solid tumors. Targeting the EGFR-mediated signaling pathway has become routine practice in the treatment of lung, pancreatic, head and neck, and colon carcinomas.

Rituximab: Uses in Dermatology

Rituximab is an anti-CD20 monoclonal antibody with considerable potential in dermatology due to an increase in off-label indications. Off-label use of rituximab, indications, side-effects, and dosing are some of the topics discussed.

Sunscreens in the Management of Photodermatoses

Key to the management of photodermatoses is photoprotection, which includes seeking shade; wearing wide brimmed hats, and sunglasses; and applying sunscreens. This article discusses sunscreens, sun protection, UVA, UVB, and its role in managing various skin conditions.

Nonablative Laser and Light Therapy: An Approach to Patient and Device Selection

Nonablative laser and light therapy is a relatively novel modality for the improvement of the visual appearance of photodamaged, scarred, and injured skin. A number of different wavelengths and devices have been purported to be efficacious for the delivery of nonablative therapy.

Pimecrolimus and Tacrolimus: The US FDA Public Health Advisory

In February of this year, the US FDA issued a public health advisory to inform healthcare providers and patients about a potential cancer risk from the topical use of pimecrolimus (Elidel©, Novartis), approved by the FDA in December 2001, and tacrolimus (Protopic©, Astellas, formerly Fujisawa), approved in December 2000.

Thalidomide

For Erythema Nodosum Leprosum there are no good alternative treatments to thalidomide. ENL is a severe and painful complication for approximately half of all leprosy patients, affecting about two million people worldwide. A review of thalidomide.

Chemical Peels

With so many new peel preparations on the market today, the dermatologist must ask himself basic questions concerning the products. The most important question is directed to the medical literature rather than the advertising or marketing campaign so common among marketdriven cosmetic products.

Tofacitinib in the Treatment of Rheumatoid Arthritis and Chronic Plaque Psoriasis

Tofacitinib is an oral immunosuppressant approved for the treatment of rheumatoid arthritis (RA) and is currently undergoing investigation (Phase III trials) for treating chronic plaque psoriasis.

Update on Drugs and Drug News: December 2002

Updates on: Prasterone Prestara™ Valacyclovir HCl Valtrex® Norelgestromin/Ethinyl Estradiol Transdermal System EVRA®

Treatment of Acne Scarring

Acne scarring is common but surprisingly difficult to treat. Scars can involve textural change in the superficial and deep dermis, and can also be associated with erythema, and less often, pigmentary change. In general, treatment of acne scarring is a multistep procedure.

Rising Drug Costs: The Impact on Dermatology

In the US prescription drug costs are rising faster than any other component of health care expenditures, and show no signs of slowing. Factors driving the rise in prescription drug costs include the introduction of new drugs, and consumer demand. (*Title Incorrect in STL Original--check--change link name)

A Review of Ixekizumab, an Anti-Interleukin-17A Monoclonal Antibody, for Moderate-to-Severe Plaque Psoriasis

Recent advances in our understanding of the innate and adaptive immune systems have led to the identification of interleukin (IL)-17 as a key pro-inflammatory mediator in psoriasis. We review phase 1-3 clinical trials of ixekizumab, for treatment of moderate-to-severe plaque psoriasis.

New Treatments for Hereditary Angioedema

Recent advances in the treatment of hereditary angioedema, particularly in the last decade has been promising. This paper reviews the mechanisms, efficacy, and adverse reactions associated with these new treatment medications. 

Psoriasis and the Pregnant Woman: What are the Key Considerations?

Pregnancy is characterized by multiple physiologic changes. Herein, we review the complicated relationships between psoriasis and pregnancy.

Pediatric Psoriasis

Several variants of psoriasis are seen in children, the most prevalent types include plaque, guttate, and psoriatic diaper rash; pustular and erythrodermic psoriasis are less frequently observed. This article discusses genetic susceptibility, and environmental triggers are discussed.

Frontal Fibrosing Alopecia

Frontal fibrosing alopecia has become one of the most frequently seen causes of scarring alopecia at many specialist hair clinics. It has distinctive features and associations which distinguish it from LPP. Discussion includes familial or genetic factors, etiology, and trials.

Update on Drugs and Drug News: April, 1999

Update on: Mupirocin Bactroban® Roxithromycin Rulid® Temoporfin Foscan®Fluticasone propionate Cutivate® Cream 17-Beta-Estradiol Vagifem® Itraconazole injection Sporanox® IV injection Becaplermin Regranex® Gel 0.1% Lidocaine/prilocaine EMLA® cream

Update on Drugs and Drug News: April 2002

Update on drugs: Fluocinolone Acetonide, Hydroquinone, Tretinoin Tri-Luma®Pimecrolimus Elidel®Clindamycin, Zinc Zindaclin™ Gel Voriconazole Vfend® Imiquimod Aldara® 5% Cream

Hair Removal Practices: A Literature Review

This article is a general overview of hair removal practices, which have evolved from utilizing waxes and blades, to advanced lasers and electrolysis, with further advancements still being studied

DSM-5 Update in Psychodermatology

This update summarizes current concepts, relevance, and therapeutics in psychodermatology, including aspects pertinent to depression, anxiety, obsessive-compulsive, impulse-control, and delusional disorders as described in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)

Botulinum Toxin Type A: New Information about an Old Medicine

Several formulations of botulinum toxin type-A (BoNT-A) are on the market in North America. This article discusses formulations, and differences in pharmacokinetics, and how it affects indications.

Photodynamic Therapy (PDT) in Dermatology: Sooner or Later?

Although PDT remains an investigational treatment modality in dermatology, several important areas of development may ultimately lead to official and practical acceptance of PDT for the skin. Various uses of PDT are evaluated.

Update on Drugs and Drug News – November 2007

Update on Terbinafine hydrochloride Lamisil® Novartis Pharmaceuticals, Famciclovir TEVA Pharmaceutical Industries, Ceftobiprole BAL5788 Basilea Pharmaceutica/Janssen-Ortho.

Concepts in a Multiprong Approach to Photoaging

Photoaging is a multisystem degenerative process that involves the skin and the skin support systems, including the bone, cartilage, and subcutaneous compartments. These structures provide the architectural support for the dermis, epidermis, and stratum corneum.

Update on Drugs and Drug News: December 2001

Update on: Tazarotene 0.1% Tazorac® Botulinum Toxin BOTOX® Tacrolimus Ointment Protopic® Amlexanox 5% paste Aptheal® Tenofovir Disoproxil Fumarate Viread™ HIV Drug Resistance Test Trugene™ HIV-1 Genotyping Test

Dermatological Management of Human Immunodeficiency Virus (HIV)

Atypical presentations of typical dermatological conditions are common in human immunodeficiency virus (HIV). This article will focus on three specific topics: eosinophilic folliculitis, psoriasis, and cutaneous mycoses. Their unique presentations in HIV and treatments are discussed.

Interleukin-17 (IL-17) Inhibitors in the Treatment of Plaque Psoriasis: A Review

Interleukin-17 (IL-17) is believed to be a potent driver of plaque psoriasis. This article reviews efficacy and safety results from Phase 2 and 3 trials with monoclonal antibodies targeting IL-17RA (brodalumab), and IL-17A (ixekizumab and secukinumab) for the treatment of plaque psoriasis.

The Surgical Correction of Protuberant Ears

While prominent ears are considered a sign of good fortune in the Far East, Western society looks upon prominent ears in a far less positive manner. Children with prominent ears are often the subjects of verbal and at times physical abuse by their peers, resulting in adverse psychological effects.

Scalp Psoriasis

Various treatment modalities for the treatment of scalp psoriasis are considered, as well as their upsides and downsides. A list of practical tips in management are also provided.

Epidermal Growth Factor Receptor Inhibitors: Cutaneous Side Effects and Their Management

Epidermal growth factor receptor (EGFR) inhibitors are part of an emerging class of anticancer medicines known as "targeted therapy". Adverse effects of such treatments are thought to be less severe, but can still be significant.

Benzoyl Peroxide: Enhancing Antibiotic Efficacy in Acne Management

Benzoyl peroxide is one of the most widely used topical agents for acne. This article discusses the anti-inflammatory and comedolytic effects of benzoyl peroxide.

Treatment of Hyperhidrosis with Botulinum Toxin A

Focal hyperhidrosis of axillae, palms or soles is a frequent, socially debilitating condition, triggered by various emotional stimuli. There are several treatment options such as local application of metal salts or tap water iontophoresis, which provide temporary relief for patients.

Methotrexate: Role of Treatment in Skin Disease

Methotrexate has been used for over half a century to treat a wide spectrum of skin conditions. This article delves into research on the pharmacogenetic properties of the drug as well as the variety of skin conditions that Methotrexate is used to treat.

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