Management of Primary Small-Vessel Vasculitis

Small-vessel vasculitides (SVV) are a group of disorders that occur due to primarily systemic inflammation or as sequelae of an infection, malignancy, or other rheumatic disease.

What is Needed for a Sunscreen to Provide Complete Protection

In order to achieve complete protection against the cumulative detrimental effects from sun exposure, topical strategies must shield against the range of solar wavelengths that can damage the skin. Existing examples of infrared-protective active agents include mitochondrially targeted antioxidants.

Blepharoplasty: Laser or Cold Steel?

Blepharoplasty of the upper and/or lower eyelids can restore a youthful appearance to the aging face. This is a minimally invasive procedure that can be accomplished with little bleeding and a small incision.

US FDA Advisory Committee Meetings Held to Discuss Isotretinoin, Safety Issues and a New Accutane Formulation

There is no drug that has provided as much therapeutic benefit for 12 million acne patients as this retinoid has done in the past 18 years following its introduction. However, it is a retinoid and, therefore, a teratogen.

Pigmentary Disorders in Asian Skin: Treatment With Laser and Intense Pulsed Light Sources

The development of selective photothermolysis has enabled removal of targets such as melanin. Both lasers and intense pulsed light (IPL) sources have been used in the treatment of pigmented lesions, however careful selection is important to ensure success.

Update on Drugs and Drug News: January 2009

Update on Ceftobiprole (Zeftera®) Johnson & Johnson/ Basilea Pharmaceuticals, IV Iclaprim Arpida Ltd., HPV Vaccine (Gardasil®) Merck & Co., Alitretinoin (Toctino®) Basilea Pharmaceuticals, and Atazanavir sulfate (REYATAZ®) Bristol-Myers Squibb.

The Role of Imiquimod 3.75% Cream in the Treatment of External Genital Warts

Imiquimod 3.75% cream has recently been approved by both the FDA and Health Canada for the treatment of external genital warts. This article is an overview of EGW, phase 3 clinical trials leading to the approval of imiquimod 3.75% cream, and comparison with imiquimod 5% cream.

Important Safety Information About DIANE®-35 and the Risk of Venous Thromboembolism

In April 2003, Berlex Canada sent out a Dear Health Care Professional letter outlining recent published information on the risk of venous thromboembolism (VTE) with DIANE®-35 (cyproterone acetate and ethinyl estradiol). DIANE®-35, like all estrogen/progesterone combinations, is associated with an increased risk of VTE.

Brodalumab: A Review of Safety

Interleukin (IL)-17 is important in the pathophysiology of psoriasis and has proven to be an effective therapeutic target. As brodalumab enters the marketplace, a review of this important biologic, its safety profile, and discussion of possible adverse effects is in order.

Update on Drugs and Drug News: July 2012

Update on drugs, approval dates, and comments. CIP-Isotretinoin (Absorica™), Tazarotene 0.1% foam (Fabior™), Butoconazole nitrate 2% vaginal cream, Multisource radiofrequency aesthetic device (Glow by EndyMed™), Low-level laser for circumferential upper arm reduction (Zerona®) are covered.

Topical Antipsoriatics

With growing public reluctance to use systemic medications we can expect topical treatments for psoriasis and other skin conditions to become increasingly important in the future. These drugs are useful not only to control this disease, but also to limit the irritation caused by medications such as tazarotene and anthralin.

Plasma Skin Regeneration Technology

Plasma skin regeneration technology uses energy delivered from plasma rather than light or radiofrequency. Plasma skin regeneration technology can be used at varying energies for different depths of effect, from superficial epidermal sloughing to deeper dermal heating.

Smoking and Skin Disease

Tobacco smoking is a serious and preventable health hazard that can cause or exacerbate a number of diseases and shorten life expectancy. This article delves into the role of smoking as an etiologic factor in the development of skin disease.

Calcipotriol and Betamethasone Dipropionate for the Treatment of Psoriasis: A 52-Week Study

Dovobet®/ Daivobet®/ Taclonex® is a product combining two molecules, calcipotriol and betamethasone dipropionate, that may offer psoriatic patients with an option for maintenance therapy. The efficacy and safety of this combined formulation when used over a 4-week period is well documented.

Hepatitis B and C Viruses and Biologics

Hepatitis B virus (HBV) and hepatitis C virus (HCV) potentially impact the clinician's ability to manage patients with immunosuppressive medications such as biological therapy. In light of recent literature reviews, patients with HBV and HCV should be referred to a hepatologist.

Sirolimus: A Therapeutic Advance for Dermatologic Disease

Sirolimus, also known as rapamycin (SRL, Rapamune®), was approved in 1999 by the US Food and Drug Administration to prevent graft rejection in renal transplantation. This articles reviews Sirolimus, its pharmacokinetics, mechanism of action, and indication.

The Dermatology Dispensing Debate

The in-office dispensing of topical skin care products by dermatologists is a source of frequent debate. Guidelines for proper dispensing have been penned by various medical organizations, yet the controversy continues. With the increasing number of physician-dispensed lines available for sale, combined with mounting medical financial issues, the ongoing debate surrounding in-office dispensing will continue.

Reducing Skin Malignancy Risk in Organ Transplant Recipients

Skin cancer in organ transplant recipients is a serious problem that manifests as increased squamous cell carcinoma in long-term patients. Education, surveillance, and management of skin cancers in high risk patients are discussed in this article.

Update on Drugs and Drug News: February 2010

Update on Imiquimod 3.75% Cream Zyclara™, Acyclovir + Hydrocortisone Cream Xerclear®/Lipsovir®, as well as drug news on Titanium dioxide (TiO2).

Update on Drugs and Drug News: September 2012

Update on Emtricitabine + tenofovir disoproxil fumarate (Truvada®), Collagenase clostridium histolyticum (XIAFLEX®) and devices such as Computer-assisted system for hair follicle harvesting (ARTAS™ System), OTC HIV test (OraQuick® In-Home HIV), and Herpes simplex virus test (IMDx HSV-1/2 for Abbott m2000).

Real-World Efficacy of Azelaic Acid 15% Gel for the Reduction of Inflammatory Lesions of Rosacea

Use of azelaic acid was associated with a significant reduction in inflammatory lesions, which persisted beyond the active treatment phase. Overall, azelaic acid 15% gel is an appropriate initial topical therapy for the treatment of moderate facial rosacea.

Update on Drugs and Drug News: May-June 2015

Update on Varicose vein n-butyl-2-cyanoacrylate adhesive polymer (VenaSeal™ Closure System), Dermal filler + calcium hydroxylapatite (CaHA) + integral 0.3% lidocaine (Radiesse®), Dalbavancin for IV injection (Xydalba™), Pembrolizumab for IV infusion (Keytruda®)

Update on Drugs and Drug News: November 2002

Updates on: Cetirizine HCl Zyrtec®Pimecrolimus Elidel® Cream Imiquimod Aldara® Cream Valacyclovir HCl Valtrex®

Topical Clascoterone for Acne Vulgaris

Clascoterone 1% cream represents a novel and promising therapeutic agent in the management of acne vulgaris for individuals ≥12 years of age. Notably, this topical agent was not observed to have significant systemic effects seen with systemic anti-androgenic agents.

Immunological Strategies to Fight Skin Cancer

Skin cancer is the most common human cancer, and is currently considered a global epidemic. Recently, there has been a growing interest in immunomodulators, or upregulators of the immune response.

Pimecrolimus 1% Cream for the Treatment of Atopic Dermatitis

Atopic dermatitis is a highly pruritic inflammatory disorder of the skin characterized by onset in infancy or childhood and a chronically relapsing course. Mainstay treatments are emollients and topical corticosteroids, but the latter are limited by side-effects from longterm use.

Update on Drugs and Drug News: April 2000

Update on: Estradiol Vaginal Ring Estring Allegra Piperonyl Butoxide/ Pyrethrins Rid Mousse Temoporfin Foscan

Update on Drugs and Drug News: September 2008

Update on Certolizumab pegol Cimzia® UCB S.A., Golimumab Centocor, Ceftobiprole medocaril ZEFTERA® Basilea Pharmaceuticals, and Tipranavir Aptivus® Boehringer-Ingelheim.

Update on Drugs & Drug News, November 2005

Updates on: Desloratadine CLARINEX® REDITABS® Dapsone ACZONE™ Gel 5% Metronidazole Metrogel® Topical Gel 1% Measles, Mumps, Rubella and Varicella Vaccine Proquad®

Rosacea: An Update on Medical Therapies

Rosacea is a common, chronic cutaneous condition that affects the face. Various conventional and emerging therapies for rosacea are reviewed.

Update on Drugs and Drug News: June 2001

Update on: Desloratidine Claritin® Azelaic Acid Cream 20% Finevin® Valganciclovir Valcyte® Dapsone Atrisone®/SMP®

Synopsis of Laser Assisted Hair Removal Systems

Conventional treatment options for hypertrichosis and hirsutism are tedious and time consuming. Laser hair removal offers an efficient way to permanently reduce excessive hair growth.

Laser Management of Acne Scarring

Acne scarring is often challenging to manage. This article discusses various laser treatments that are helpful in addressing abnormal color and texture in order to improve the appearance of an acne scar as well as review the appropriate use and side-effects of these treatments.

Adapalene 0.1% and Benzoyl Peroxide 2.5%: A Novel Combination for Treatment of Acne Vulgaris

Topical products commonly used to treat acne include retinoids and antimicrobials, due to their effects on different components of pathogenesis. Accordingly, a fixed combination of adapalene 0.1% and benzoyl peroxide (BPO) 2.5% was developed (Epiduo™, Galderma) and was approved by the US FDA for the treatment of acne.

Update on Drugs and Drug News: March 2002

Updates on: Naturally-Derived Alpha Interferon Efavirenz Sustiva®Estradiol/Levonorgestrel Alesse®HSPPC-96 Oncophage®Tenofovir Disoproxil Fumerate Viread® Desloratidine Clarinex® 5mg. Tablets

Update on Drugs & Devices: May – June 2019

Latest drug update covers Pembrolizumab for IV injection (Keytruda®, Merck & Co.), Guselkumab for SC injection (Tremfya®, MorphoSys/Janssen), Dupilumub for SC injection (Dupixent®, Regeneron), and Risankizumab for SC injection (Skyrizi™, AbbVie).

Utilization of Topical Ruxolitinib in Dermatology: A Review

Topical ruxolitinib shows promise in various dermatological conditions, including atopic dermatitis, vitiligo, psoriasis, and lichen planus, with a favorable safety profile compared to oral JAK inhibitors. However, its effectiveness in alopecia areata remains inconclusive.

Urticaria and Angioedema: A Rational Approach to Diagnosis and Therapy

Urticaria and angioedema and some forms of this disorder may be increasing in both prevalence and severity due to changes in medications, environment and other factors. This review focuses on a rational approach to differential diagnosis and therapy of the most common forms of urticaria and angioedema.

Update on Drugs & Devices: July-August 2022

Update covering: Benzoyl peroxide 5% cream, Isotretinoin ointment, Tapinarof 1% cream, Baricitinib tablets, and Dupilumab for SC injection.

A Review of Ixekizumab, an Anti-Interleukin-17A Monoclonal Antibody, for Moderate-to-Severe Plaque Psoriasis

Recent advances in our understanding of the innate and adaptive immune systems have led to the identification of interleukin (IL)-17 as a key pro-inflammatory mediator in psoriasis. We review phase 1-3 clinical trials of ixekizumab, for treatment of moderate-to-severe plaque psoriasis.