- Proper patient counseling of the risks versus benefits of is very important to ensure compliance with therapy. Awareness of the possibility of transient exacerbation of acne is important.
- Check that the drug is being taken with fatty food to enhance drug absorption
- Actively manage the side-effects. Remember that topical antibiotics and occasionally topical corticosteroids may be required for the skin, lip side-effects
- The dose can be lowered temporarily if fatigue, joint pains ,mood changes or if other side-effects are very troubling and might interfere with continuing therapy.