UPDATE ON DRUGS | ||
| Class | Name/Company | Approval Dates and Comments |
Antiviral Agent | Zoster Vaccine Live Zostavax®
| The US FDA approved this new vaccine in May 2006 for the prevention of herpes zoster (shingles) in individuals 60 years of age and older. It is given as a single dose by injection. |
Rosacea | Doxycycline, 40mg Oracea®
| The US FDA approved this product in May 2006 for the treatment of inflammatory lesions (papules and pustules) of rosacea in adult patients. |
Antiaging Agent | Hyaluronic Acid Dermal Filler Juvéderm® Gel Allergan | The US FDA approved this dermal filler in June 2005 for the treatment of facial wrinkles and folds. Juvéderm® should only be administered by a trained and qualified health care provider. |
Immunomodulatory Agent | Mycophenolate Mofetil CellCept® Aspreva Pharmaceuticals/Roche | The US FDA granted orphan drug designation for this immunosuppressive agent in June 2006 for the treatment of pemphigus vulgaris. |
Oncologic Agent | Suberoylanilide Hydroxamic Acid (SAHA) Zolinza® Merck | The US FDA accepted a New Drug Application for this investigational histone deacetylase inhibitor in June 2006 for the treatment of advanced cutaneous T-cell lymphoma. This NDA has been granted priority review. |
Vaccine | Quadrivalent Human Papillomavirus Recombinant Vaccine Gardasil® Merck | The US FDA approved this vaccine in June 2006 for the prevention of cervical cancer and vulvar and vaginal precancers caused by HPV types 16 and 18 and to prevent low-grade and precancerous lesions and genital warts caused by HPV types 6, 11, 16 and 18. |
TNF-blocking Agent | Adalimumab Humira® | The European Medicines Agency approved this tumor necrosis factor (TNF)-blocking agent in June 2006 for the treatment of severe ankylosing spondylitis. |
Drug News | |
Antipsoriatic Agent | Twelve-week data were recently published* from a multinational, randomized, double-blind, placebo-controlled, parallel-group clinical study designed to evaluate the safety and efficacy of efalizumab (Raptiva®) 1.0mg/kg once weekly when compared with placebo. Investigators found that efalizumab produced significant clinical improvements and was generally well tolerated among patients with moderate-to-severe plaque psoriasis. *Dubertret L, Sterry W, Bos JD, et al. Br J Dermatol 155(1):170-81 (2006 Jul). |
Treatment Resistance | According to a recent study of Welsh school children published in the Archives of Disease in Childhood*, four out of five head lice are resistant to common treatments containing pyrethroids (permethrin and phenothrin). Whether this pattern is reflected elsewhere will depend on how head lice treatments are used. However, they suggest that where resistance develops, a newer silicone based lotion might be a suitable alternative. *Thomas DR, McCarroll L, Roberts R, et al. Arch Dis Child [Epub ahead of print] (2006 June 14). |
