UPDATE ON DRUGS

Class Name/Company Approval Dates and Comments

Antiviral Agent
Zoster Vaccine Live
Zostavax™
Oka/Merck
The US FDA received a Biologics License Application in April 2005
for this investigational vaccine for the prevention of herpes zoster, the
prevention of postherpetic neuralgia, and the reduction of acute and
chronic shingles-associated pain in adults.

Wound Management
Antimicrobial Barrier Dressing
ACTICOAT* Moisture Control
Smith & Nephew
The US FDA approved this product in May 2005 for wound
care as a barrier to bacterial penetration, featuring the patented
Silcryst™ nanocrystalline silver technology.

Antibacterial Agent
Meropenem for Injection
MERREM®
AstraZeneca
The US FDA approved this antibiotic in May 2005 for the
treatment of complicated skin and skin structure infections in
adults and children.

Antipsoriatic Agent
Etanercept
Enbrel®
Amgen/Wyeth Pharmaceuticals
The US FDA approved an additional indication for this tumor
necrosis factor receptor in June 2005 to improve physical
function in patients with psoriatic arthritis.

Drug News

Cancer Vaccine CancerVax, in April 2005, announced plans to discontinue the Phase III clinical trial of
Canvaxin™ in patients with Stage IV melanoma on the basis of the recommendation of the
Independent Data and Safety Monitoring Board (DSMB). The DSMB, after a limited review
of the trial found that the data are unlikely to provide significant evidence of a survival benefit
for Canvaxin-treated patients with Stage IV melanoma vs. those receiving placebo. There were
no safety issues identified, and the recommendation to close the study was not made because of
any potential safety concern. It is anticipated that the final analysis of data from this clinical trial
will take place after the required number of clinical events have occurred, currently estimated to
take place in mid-2006.

Antipsoriatic Agent
Serono, in April 2005, announced the discontinuation of a Phase III clinical trial program for
onercept (recombinant tumor necrosis factor binding protein) in moderate-to-severe psoriasis.
Investigators reported two patients who were diagnosed with sepsis, one of whom subsequently
died. Sepsis is a recognized potential risk for patients treated with anti-tumor necrosis factor
therapies. The Independent Data and Safety Monitoring Board (DSMB) evaluated the available
blinded efficacy data at 12 weeks, and data from the first 12 weeks of an open-label trial. Based
on these aggregate data, they determined that the efficacy response observed for onercept was
less than that observed in the earlier phase II trial, and with other available treatments. As a
consequence of its unfavorable risk-benefit profile, the DSMB recommended discontinuation of
the clinical development of onercept in moderate-to-severe psoriasis.