Methotrexate: Role of Treatment in Skin Disease
Methotrexate has been used for over half a century to treat a wide spectrum of skin conditions. This article delves into research on the pharmacogenetic properties of the drug as well as the variety of skin conditions that Methotrexate is used to treat.
Dupilumab for Moderate-to-Severe Atopic Dermatitis
Despite a rising prevalence, effective and safe therapeutics for patients with moderate-to-severe AD are limited due to toxicity and side effects. Dupilumab, an interleukin (IL)-4 and IL-13 antagonist that limits type 2 T helper (Th2) driven inflammatory activity, is a promising therapeutic option.
Alternative Treatments For Atopic Dermatitis: A Selected Review
Herbal remedies are largely unregulated, but often talked about among patients. Many may have scientific merit and clinical benefit, but they are still scientifically invalid and inadequately monitored. Dermatologists need information about herbal remedies to better serve their Atopic Dermatitis patients.
Treatment of Eczema Complications
Eczema creates several complications such as bacterial and viral infections due to exposed skin - from cracking. This article delves into these complications that can arise out of eczema and how to treat them.
Management of Chronic Hand Dermatitis: A Practical Guideline for the General Practitioner
Hand Dermatitis can have a significant impact on quality of life. It may interfere with activities both at work and in the home and can be associated with social and psychological distress. This article provides helpful practical guidance for the general practitioner in the management of patients with Hand Dermatitis.
Diagnosis and Management of Atopic Dermatitis for Family Physicians: A Clinical Review
Atopic dermatitis (AD) is a chronic and pruritic inflammatory disease that affects a wide age range of patients causing significant impact on their quality of life. There has been a recently updated consensus paper on the treatment of mild-to-moderate AD published by an expert panel of dermatologists and pediatricians. Family physicians are well equipped to manage...
A Review of Prednicarbate (Dermatop®)
Prednicarbate is a nonhalogenated corticosteroid that is used in the treatment of inflammatory skin diseases, for example atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy.
Alitretinoin: An Update of Real-World Evidence in The Management of Chronic Hand Dermatitis
Alitretinoin is an oral retinoid which has proven efficacy and safety in the treatment of chronic hand dermatitis through randomized controlled trials.
The Role and Topical Management of Staphylococcus aureus in Atopic Dermatitis (Pediatric)
This article discusses the role of S. aureus, on atopic dermatitis. Taking a proactive approach to treatment, and control S. aureus may have benefits for the management of inflammation.
Tacrolimus Ointment (Protopic®) for Atopic Dermatitis
Tacrolimus ointment (Protopic®, Fujisawa) is an effective agent in a class of topical immunomodulators. It has been shown to be safe and effective in adults and children with Atopic Dermatitis in short- and long-term treatments.
Topical corticosteroids have been a mainstay of eczema therapy. This article is a comprehensive list of various indications, contraindications, combination therapies, and differing strengths of steroids.
Treatment of Hand Eczema
Hand eczema is a common skin disease that tends to become chronic and may interfere with many types of work. Emollients have been shown to be useful in reducing eczema activity and in the primary prevention of hand eczema.
Eczema Oral Treatment
Oral treatments for treating eczema: Antibiotics, antihistamines, corticosteroids and cyclosporine A are the focus of this article.
Crisaborole 2% Ointment for Mild-to-Moderate Atopic Dermatitis
Crisaborole provides a novel and safe treatment option for mild-to-moderate AD.
FDA Issues Public Warning Re Elidel and Protopic
A summary on the FDA warning on Elidel and Protopic. Commentary from organizations like the American Academy of Dermatology, Canadian Dermatology Association, National Eczema Association for Science and Education and Inflammatory Skin Disease Institute are also linked here.
Management of Eczema
The prevalence of eczema is increasing over the past 30 years, and is estimated to affect 20% of children in North America and Northern Europe. This article discusses eczema, incidence, clinical presentations, and management, as well as specific primary and second line therapies.
Chronic Hand Dermatitis: Case-based Approaches to Management
Practical guidelines for the management of Chronic Hand Dermatitis were published in the Skin Therapy Letter, Family Practice Edition (October 2016). This series of cases using Alitretinoin (Toctino®), is a follow on to that publication to put the guidelines into context.
Pimecrolimus 1% Cream (Elidel®) For Atopic Dermatitis
Pimecrolimus is an immunomodulating medication that inhibits production of inflammatory cytokines in the skin and this compound was specifically developed for the treatment of inflammatory skin diseases.
Non-Pharmacologic Management of Atopic Dermatitis
Atopic dermatitis (AD) or eczema is a chronic, relapsing skin condition that can lead to xerosis, pruritus, and patches of dermatitis. Coping with the physical and emotional aspects of AD can significantly impact the quality of life. It is most common in childhood, as many patients seem to outgrow the condition by adulthood.
Atopic Dermatitis: The Skin Barrier and the Role of Ceramides
This paper examines the pathogenesis of atopic dermatitis, the skin barrier, and the role that ceramides can play in therapy.
Objectives of Eczema Therapy
Eczema is a chronic condition, and a very common one so long-term symptom controls are critical. This article focuses on the major objectives of eczema treatment.
Allergic Contact Dermatitis to Preservatives and Fragrances in Cosmetics
Cosmetics are an important cause of allergic contact dermatitis (ACD). Fragrances and preservatives are the two most clinically relevant allergens found in cosmetic products. Common cosmetic allergens are reviewed. Practical methods of allergen avoidance are also discussed.
Moisturizers: What They Are and a Practical Approach to Product Selection
Moisturizers are widely used products that are important in many dermatologic and cosmetic skin therapies. They contain varying combinations of emollients, occlusives, and humectants to achieve their beneficial effects, and there is an overwhelming number of formulations available.
Flares in Childhood Eczema
Eczema is a major public health problem affecting children worldwide. Few studies have directly assessed triggers for disease flares. This information is likely to be useful to families and may lead to the ability to reduce disease flares in the future.
Itraconazole (Sporanox®) for Seborrheic Dermatitis
Seborrheic dermatitis is a common superficial dermatosis, characterized by red, flaking areas of the skin, which may in some cases be covered with yellowish flakes. The most commonly affected areas are the nasolabial folds, ears, eyebrows, scalp and chest.
This article discusses the concept of the treatment triangle: Evidence based treatment, treatment based on evidence and clinical experience, and patient preference, and how these concepts intersect.
Review of Evidence for Dietary Influences on Atopic Dermatitis
Atopic dermatitis is a chronic inflammatory skin disease affecting children and adolescents worldwide. This articles reviews the potential relationship of atopic dermatitis to diet and the effectiveness of elimination diets and diet supplementation in the management of AD.
Practical Management Strategies for Diaper Dermatitis
Common diaper dermatitis is an irritant contact diaper dermatitis (IDD) created by the combined influence of moisture, warmth, urine, feces, friction, and secondary infection. This article will focus on practical management strategies for IDD.
The Role and Topical Management of Staphylococcus aureus in Atopic Dermatitis (Family Practice)
Atopic dermatitis (AD), or eczema, is a common, chronic, relapsing, genetically determined inflammatory skin disorder. This article discusses the role of Staphylococcus aureus (S. aureus) as a factor to consider.
Therapeutic Moisturizers in Eczema and Xerosis Management (Pharmacist Edition)
Eczema is a chronic relapsing dermatitis and, as such, it is imperative to maintain the hydration and barrier function of the skin in these patients with daily moisturizer use. This article discusses TEWL, ceramide and urea based moisturizers, and other ways to maintain barrier function.
Seborrheic Dermatitis: New Formulations for Treatment
Seborrheic dermatitis is a common cutaneous disorder occurring in at least 3%–5% of the population. We discuss new treatment formulations and protocols.
Management of Adult Moderate-to-Severe Atopic Dermatitis: A Practical Guide for Primary Care
Atopic dermatitis (AD) is a chronic, relapsing, pruritic, inflammatory condition involving the skin which can have a significant impact on the quality of life. This article will guide the family practitioner on how to manage adults with moderate-to-severe AD and when to refer for specialist management.
An Overview of Parabens and Allergic Contact Dermatitis
Parabens have been under scrutiny for some time with the very limited reports of paraben-induced allergic contact dermatitis. This article discusses the controversy, the data, and how the facts may not match up with the concern.
Eczema Light Therapy
Phototherapy, Narrow Band UVB, and PUVA are an important branch of treatment for some people with eczema. This article discusses some of the options available in terms of light therapy.
A Look at Epidermal Barrier Function in Atopic Dermatitis: Physiologic Lipid Replacement and the Role of Ceramides
This review summarizes and discusses the role and efficacy of moisturizers, particularly the more recently introduced ceramide-based formulations, in the skin care regimen of patients with both active and quiescent atopic dermatitis.
Topical Corticosteroid Dosing, Mechanisms of Action, & Prescribing
Topical corticosteroid dosing, mechanism of action and prescribing advice is provided in this article. General rules, prescribing suggestions, precautions, and side-effects are discussed.
Steroid-Sparing Properties of Emollients in Dermatology
This article reviews topical corticosteroids (TCS) and topical calcineurin inhibitors (TCIs) to manage inflammatory conditions, its risks with long-term use, and the role of moisturizing as important therapeutic adjuncts.
The Treatment of Atopic Dermatitis and Other Dermatoses with Leukotriene Antagonists
The exact mechanism of action of leukotriene receptor antagonists in Atopic Dermatitis is not known. In small clinical and case studies, montelukast was found to be a safe and effective alternative or steroid-sparing therapy in the management of patients with atopic dermatitis.
Ciclopirox Shampoo for Treating Seborrheic Dermatitis
Seborrheic dermatitis is a common inflammatory skin disease, affecting between 1% and 3% of immunocompetent adults. While its cause is unknown, a number of predisposing factors have been reported, including the implications of Malassezia yeasts.
Atopic Dermatitis: A Practical Guide to Management
A group of dermatologists with extensive experience in managing pediatric and adult patients with atopic dermatitis developed practical recommendations for the management of atopic dermatitis based on expert consensus opinion and the best available medical evidence.
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