G.D. Schachter, MD
Division of Dermatology, Sunnybrook & Women’s College Health Science Centre, Toronto, ON, Canada
Psoriasis is a chronic, unpredictable, T cell mediated, inflammatory, papulosquamous
condition that affects approximately 2%-3% of any population.
- The average age of onset is mid- to late-20s, although onset may occur at any age.
- Psoriasis is characterized by accelerated proliferation of epidermal cells (keratinocytes), vascular proliferation, and an influx of inflammatory cells (neutrophils, macrophages, and activated T cells).
- Involvement of the scalp may be minimal (few plaques) or more significant. The entire scalp can be involved.
- Hair loss may be seen with significant involvement of the scalp, and is non-scarring. Hair should regrow when the psoriasis clears.
Psoriasis affects the skin, especially extensor surfaces and also the scalp, body folds, and nails. The scalp may be the most frequently involved area. Approximately 15%-30% of patients have an associated arthritis.
There is a genetic basis to psoriasis with an increasing risk of developing the disease if one or both parents have psoriasis. The activated T cell plays a pivotal role in the pathogenesis of the disease.
- Psychosocial distress (markedly affects quality of life)
- Hair loss with severe involvement
The classic lesion is a well-demarcated, erythematous plaque with a silvery scale. When the scale is removed, bleeding points are seen (Auspitz sign). Psoriasis can develop after trauma and lesions worsen with rubbing or scratching (Koebner phenomenon).
Forms/Types of Lesions
- Chronic Plaque
- Pustular – Localized or Generalized
- Hormones – Pregnancy
- Drugs – Beta-Blockers, Lithium, Anti-Malarials
- Systemic Steroid Withdrawal
- Infections – Viral and Streptococcal
- Seborrheic Dermatitis – common
- Lichen Planus – unlikely
- Fungal Infection – unlikely
- Lupus Erythematosus – unlikely
Scalp Psoriasis vs. Scalp Seborrheic Dermatitis
Scalp Seborrheic Dermatitis
|Silvery white, dry scales||Yellow, greasy scales|
|Well demarcated||Poorly defined|
|Can extend onto forehead (check nails, extensor surfaces)||Remains within scalp hairline (check eyebrows, sides of
Seborrhiasis presents with features of both psoriasis and seborrheic dermatitis. Psoriasis of the scalp is primarily treated locally with topical treatments. Systemic therapies are usually reserved for more widespread or severe forms of psoriasis.
Resistant or recalcitrant psoriasis of the scalp may require intralesional injections of corticosteroids, and less frequently a systemic treatment.
Treatments for Psoriasis
- Coal Tar
– Compounded with corticosteroids
- Wood Tar
– Anthralin (Infrequently used in North America; still popular in Europe)
- Coal Tar
- Lotion (e.g., betamethasone valerate)
- Gel (e.g., fluocinonide)
- Foam (Not available in Canada)
- Shampoo (e.g., clobetasol propionate (Clobex®))
- Oil and Corticosteroid (Dermasmoothe® FS oil)
- Vitamin D3 Analogues
- Calcipotriol (Dovonex® Scalp Solution)
- Calcipotriol + betamethasone dipropionate (Dovobet®)
- Salicylic Acid 5%-15% in mineral oil
- Tar (T-Gel® or Sebcur T®)
- Salicylic Acid (Sebcur®)
- Zinc Pyrithione (Dangard® or Head & Shoulders®)
- Ketoconazole (Nizoral®) or Ciclopirox (Stieprox®)
- Potent Corticosteroid (Clobex®/Clobetasol®)
- Narrow Band
- PUVA – oral, bath, soaks
- Phototherapy (Rarely used for scalp) – Innovative “comb” to deliver ultraviolet light
- Acitretin (Neotigason®)
- Cyclosporin – A
- Alefacept (Amevive®)
- Etanercept (Enbrel®)
- Efalizumab (Raptiva®)
Intralesional Corticosteroid Injections (Triamcinolone / Kenalog Injections)
Combination or Rotational Treatments
Mild-to-moderate cases of scalp psoriasis
- Gently shampoo scalp every morning (use palms NOT fingertips)
- Apply a corticosteroid gel or lotion once or twice per day
- Apply calcipotriol (Dovonex®) solution once or twice per day
- Antihistames (hydroxyzine or doxepin) at night for itching
Moderate-to-severe cases of scalp psoriasis
- Apply oil and salicylic acid or Dermasmooth FS® oil at bedtime and wear a shower cap
- Resistant plaques can be injected with Triamcinolone 2.5-4 mg/u every 3 or 4 weeks as necessary
- Antihistamines (hydroxyzine or doxepin) at night for itching
It should be noted that rarely scalp psoriasis is severe enough to require systemic agents such as methotrexate or acitretin.
- Do not rub, scratch, pick, or brush/comb roughly.
- Treat gently.
- Do not pick off scale.
- Trauma or surgery will cause the plaques to flare (thicker, scalier plaques, larger areas).
Psoriasis remains a therapeutic challenge. Involvement of the scalp can be minimal (“dandruff”) or more significant and difficult to manage. Gentle treatment, reducing trauma, and treating the inflammation and pruritus will improve therapeutic results.