Psoriatic Arthritis

Read articles about psoriatic arthritis and its management, and its treatment options.

TNF-a Inhibitors in Dermatology

To date, the US FDA has approved three tumor necrosis factor (TNF)-a inhibitors for use in dermatology. The distinct and targeted mechanism of action of the TNF inhibitors allows dermatologists to customize therapy to match the individual needs and characteristics of patients who are candidates for systemic therapy.

Biologic Therapy and Risk of Infection

Biologic compounds are being used more frequently to treat a multitude of systemic inflammatory conditions. This article discusses the increased risk of opportunistic infections of tuberculosis, herpes zoster, Legionella pneumophila, and Listeria monocytogenes.

Etanercept, a TNF Antagonist for Treatment of Psoriatic Arthritis and Psoriasis

Etanercept (EnbrelĀ®, Amgen and Wyeth), a tumor necrosis factor (TNF) antagonist, was approved in January 2002, for the treatment of psoriatic arthritis (PsA). Etanercept was evaluated for the treatment of PsA and psoriasis in a preliminary study of 60 patients and in a confirmatory phase III study of 205 patients.

Apremilast in the Treatment of Psoriasis and Psoriatic Arthritis (Family Practice)

Phosphodiesterase 4 (PDE4) is a key enzyme in the regulation of immune responses of inflammatory diseases through degradation of the second messenger, cyclic adenosine 3',5'-monophosphate (cAMP). Apremilast (APR), a selective PDE4 inhibitor, has been shown to reduce the production of pro-inflammatory cytokines.

Sulfasalazine

Sulfasalazine is the only drug that was developed specifically for arthritis and combines a sulfa drug with acetylsalicylic acid. This article discusses the use of sulfasalazine for treating psoriatic arthritis.

Azathioprine

Azathioprine is used as an immunosuppressive agent used to control transplant rejection. It is also being used to treat psoriatic arthritis. This article reviews the case for its use for this purpose.

Topical Antipsoriatics

With growing public reluctance to use systemic medications we can expect topical treatments for psoriasis and other skin conditions to become increasingly important in the future. These drugs are useful not only to control this disease, but also to limit the irritation caused by medications such as tazarotene and anthralin.

Psoriatic Arthritis Treatment – The Objective of Therapy

This article discusses the main objectives of psoriatic arthritis treatment and management. Expectations, as well as specific symptoms like joint stiffness are discussed.

Topical Antipsoriatic Treatments in 2007

Advancements in topical antipsoriatic therapies have provided safer and more effective treatment options, especially when used in combination. Consequently, much research is underway to investigate novel treatment combinations for psoriasis in the hope that it will provide further enhancements in efficacy.

Psoriatic Arthritis – Other Medical Treatments

This article discusses other treatments for psoriatic arthritis that are often used in complement to other treatment modalities like methotrexate. Surgery, physiotherapy, gold, and anti-malarial treatments are all discussed.

Leflunomide

Leflunomide was initially developed for use in the treatment of cancer and has been used successfully in rheumatoid arthritis. This article discusses the use of leflunomide for the treatment of psoriatic arthritis.

Psoriatic Arthritis Treatment – Immunobiologics

This article provides an important overview of the mechanisms and objectives in using immunobiologics to control psoriatic arthritis.

Methotrexate

Methotrexate, originally an anti-cancer drug, has been used to treat psoriasis and psoriatic arthritis effectively. This article discusses methotrexate, including side-effects drug interactions, and tests, as well as efficacy in the context of treating psoriatic arthritis.

Cyclosporin A

Cyclosporin A, originally used as a drug used to fight organ rejection - is used to treat psoriatic arthritis. Its mechanism of action, mode of administration, and side effects are discussed.

Risankizumab in Adults with Psoriatic Arthritis

Explore risankizumab for Psoriatic arthritis: Beyond ACR, it significantly improves enthesitis, dactylitis, and QoL scores like HAQ-DI. Promising in efficacy and safety, with full 208-week study results anticipated for a complete understanding.

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