STL Volume 18 Number 6

Update on Dabrafenib mesilate capsule (Tafinlar™), Trametinib dimethyl sulfoxide tablet (Mekinist™), and Vismodegib capsule (Erivedge®)

Infantile hemangiomas are the most common tumors occurring in early childhood, with a prevalence of approximately 5-10% of infants. Discussions centres around β-blockers, which appear to be highly effective in treating IH are at the centre of discussion.

Current practice guidelines recommend administration of oral isotretinoin with high-fat meals, which may pose issues with patient compliance. This article discusses Isotretinoin-Lidose (Epuris™), pharmacokinetics, bioavailability, and increased drug absorption rate, and how it may improve patient compliance.