Topical Treatment of Psoriasis in Children

Psoriasis is a common dermatosis, affecting children in North America. Many papers have stressed the treatments available for adult psoriasis, but few have dealt with this disorder in children. Topical treatment modalities continue to be the first line therapy for childhood psoriasis.

Pimecrolimus 1% Cream (Elidel®) For Atopic Dermatitis

Pimecrolimus is an immunomodulating medication that inhibits production of inflammatory cytokines in the skin and this compound was specifically developed for the treatment of inflammatory skin diseases.

Update on Drugs and Drug News: March 2002

Updates on: Naturally-Derived Alpha Interferon Efavirenz Sustiva®Estradiol/Levonorgestrel Alesse®HSPPC-96 Oncophage®Tenofovir Disoproxil Fumerate Viread® Desloratidine Clarinex® 5mg. Tablets

Common Sense Dermatological Drug Suggestions For Women Who Are Breast-feeding

Use of medications by breast-feeding mothers is not uncommon. Information regarding the safety of common dermatological medications during lactation will be reviewed. Based on this information, treatment recommendations will be made.

Topical Tazarotene Therapy for Psoriasis, Acne Vulgaris, and Photoaging

Psoriasis, acne vulgaris and photoaging are common conditions. Tazarotene is a pro-drug of tazarotenic acid, a receptor-selective retinoid, which has shown efficacy in the treatment of these disorders. In the treatment of acne vulgaris, it has greater comedolytic activity than the currently available topical retinoids.

Update on Drugs and Drug News: February 2002

Updates on: Desloratidine Syrup & Disintegrating Tablets Moxifloxacin HCl IV Avelox®Photodynamic Therapy Metvix® PDT Etanercept Enbrel® Hydroquinone, Tretinoin & Flucinolone Cream Tri-Luma®

Drug Treatments for Skin Disease Introduced in 2001

An overview and update of skin conditions and treatments introduced in 2001: Quick overview of drug name, indications and regulatory status

Alternative Treatments For Atopic Dermatitis: A Selected Review

Herbal remedies are largely unregulated, but often talked about among patients. Many may have scientific merit and clinical benefit, but they are still scientifically invalid and inadequately monitored. Dermatologists need information about herbal remedies to better serve their Atopic Dermatitis patients.

Update on Drugs and Drug News: January 2002

Update on: Pimecrolimus Elidel®Butenafine HCl 1% Cream Lotrimin Ultra®Doxycycline Vibramycin®Fluocinolone acetonide Derma-Smoothe/FS®Doxycycline Thalidomid®

Treatments Of Choice For Bullous Pemphigoid

Bullous pemphigoid (BP) is the most frequently occurring autoimmune blistering disease in Europe and North America. Although it is primarily a disease of the elderly, children and young adults can also develop it.

Topical Metronidazole for Rosacea

Rosacea is relatively common, typically occurring in individuals of Northern European and Celtic origin between 30 and 50 years of age. It is more common in women, but may be more severe in men. Currently there is no cure available for rosacea, but it can be controlled with topical and oral drug therapy.

Update on Drugs and Drug News: December 2001

Update on: Tazarotene 0.1% Tazorac® Botulinum Toxin BOTOX® Tacrolimus Ointment Protopic® Amlexanox 5% paste Aptheal® Tenofovir Disoproxil Fumarate Viread™ HIV Drug Resistance Test Trugene™ HIV-1 Genotyping Test

Moisturizers: What They Are And How They Work

Moisturizers are widely used in various dermatologic and cosmetic skin therapies. Different classes of moisturizers are based on their mechanism of action, including occlusives, humectants, emollients and protein rejuvenators.

Update on the Botulinum Neurotoxins

The botulinum neurotoxins (BTX) are an exciting group of therapeutic agents with dramatically expanding clinical indications. The US FDA has approved BOTOX® (BTX-A, Allergan) and Myobloc™ (BTX-B, Elan Pharmaceuticals) for the treatment of cervical dystonia.

Update on Drugs and Drug News: November 2001

Update on: Etanercept Enbrel® Clindamycin 1%, Benzoyl Peroxide 5% BenzaClin™ Ethinylestradiol & Norethindrone Acetate Estrostep Desloratadine Aerius™ & Neoclarityn™ Agalsidase Alfa Replagal™ Ciprofloxacin Butenafine HCl Mentax®

Treatments for Chronic Palmoplantar Pustular Psoriasis

Chronic palmoplantar pustular psoriasis is a disabling condition characterized by recurrent crops of sterile pustules on a background of erythema, fissuring and scaling. Genetic and environmental factors have been implicated in its etiology.

Famciclovir Therapy (Famvir®) for Herpes Simplex and Herpes Zoster Infections

Genital herpes simplex and herpes zoster infections are common afflictions that are associated with significant morbidity and a decreased quality of life. Famciclovir (Famvir®, Novartis) is an orally administered prodrug of the antiviral agent penciclovir.

Update on Drugs and Drug News: October 2001

Update on: Valacyclovir HCl Valtrex®Tretinoin Gel Retin-A® Micro® Microsphere Drospirenone/Ethinyl Estradiol Yasmin®Agalsidase Beta Fabrazyme™

Treatment of Hemangiomas in Children

Their management of hemangiomas has been controversial as they are unpredictable. Today there is an increased awareness of both the physical and psychological sequelae associated with hemangiomas, a small percentage of which can be life threatening. This has resulted in a renewed push to treat them.

Moxifloxacin (Avelox®) For The Treatment Of Bacterial Skin Infections

Moxifloxacin (Avelox®, Bayer), which is available for oral administration, is a broad-spectrum synthetic antimicrobial agent with excellent Gram-positive activity and good Gram-negative activity. The US FDA recently approved this drug for the treatment of bacterial skin infections.

Aminolevulinic Acid (Levulan®) in Photodynamic Therapy of Actinic Keratoses

The role of photodynamic therapy (PDT) in the treatment of in situ neoplasias and tumors of the skin is steadily increasing. Its principles of photodynamic action include an intratumoral enriched photosensitizer and light activation.

Update on Drugs and Drug News: September 2001

Updates on: Aminolevulinic Acid Levulan® Kerastick™ photodynamic therapy Infliximab Remicade™ Butenafine HCl Mentax®Clotrimazole/Betamethasone Dipropionate

Vulvovaginal Dryness and Itching

Dryness and itching in the vulvovaginal area is an increasing problem as our female population ages and becomes menopausal. This dryness and itching is often the result of estrogen deficiency, and there are typically two types of treatment: Specific Therapy (or hormone replacement therapy), and Nonspecific Therapy.

Update on Drugs and Drug News: June 2001

Update on: Desloratidine Claritin® Azelaic Acid Cream 20% Finevin® Valganciclovir Valcyte® Dapsone Atrisone®/SMP®

5-Fluorouracil 0.5% Cream for Multiple Actinic or Solar Keratoses of the Face and Anterior Scalp

Carac® (5-fluorouracil 0.5% cream, Aventis Pharma) was approved by the US FDA in October 2000, for the treatment of multiple actinic or solar keratoses involving the face and anterior scalp.

Update on Drugs and Drug News: May 2001

Update on: Moxifloxacin HCl Avelox Recombinant Human Iduronidase (IDUA) Neurotoxins Botox Graftskin Apligraf

Antidepressant Drugs in Dermatology

Antidepressant drugs can be an important component of the dermatologist’s armamentarium. Specific guidelines, side effect profile, drug-drug interactions, and the current indications should always be obtained for any particular antidepressant agent before it is prescribed.

A New Formulation Containing Sunscreen (SPF-15) And 1% Metronidazole (ROSASOL Cream) In The Treatment Of Rosacea

ROSASOL Cream is a novel topical formulation of 1% metronidazole in a vehicle containing sunscreens (SPF 15). This product has demonstrated efficacy in the treatment of inflammatory lesions, erythema, and telangiectasiae associated with rosacea.

Update on Drugs and Drug News: April 2001

Update on: Arsenic Trioxide Trisenox Transdermal 17-Beta Estradiol Estradot Methotrexate Trexall

Treatment of Toxicodendron Dermatitis (Poison Ivy And Poison Oak)

Toxicodendron dermatitis results from a reaction to an oil soluble oleoresin that is present in many parts of the poison ivy and poison oak plants. Prophylactic measures and treatments are discussed.

Vaniqa – Eflornithine 13.9% Cream

Eflornithine HCl 13.9% cream (Vaniqa) is the first topical prescription treatment to be approved for the reduction of unwanted facial hair in women. It irreversibly inhibits ornithine decarboxylase, an enzyme that catalyzes the ratelimiting step for follicular polyamine synthesis, which is necessary for hair growth.

Update on Drugs and Drug News: March 2001

Update on: Caspofungin Acetate Cancidas 5% Minoxidil Topical Solution Mequinol 2%, Tretinoin 0.1% Solagé Topical Solution Biologically Active Dressing Composite Cultured Skin (CCS) Xtrac Excimer Laser System

Imiquimod Applied Topically: A Novel Immune Response Modifier

Imiquimod (S-26308, R-837) (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4 amine), an immune response modifier, was approved as a 5% cream (Aldara, 3M Pharmaceuticals) by the US FDA in February 1997, for the treatment of genital and perianal warts.

Update on Drugs and Drug News: February 2001

Update on: Loratidine Claritin Varicella Zoster Immune Globulin VariZIG Levocetirizine Xyzal/Xusal Agalsidase Beta Fabrazyme ASM 981 Cream 1%

Drug Treatments For Skin Disease Introduced in 2000

An overview and update of skin treatments introduced in 2000: Quick overview of drug name, indications and regulatory status

Oral Contraceptives in the Treatment of Acne

Oral contraceptives (OCs) can reduce acne by lowering the production of adrenal and ovarian androgens, by inhibiting 5- alpha-reductase, which in turn, reduces the levels of dihydrotestosterone, and by stimulating sex hormone binding globulin (SHBG), thus reducing the levels of free testosterone.

Topical Antipsoriatics

With growing public reluctance to use systemic medications we can expect topical treatments for psoriasis and other skin conditions to become increasingly important in the future. These drugs are useful not only to control this disease, but also to limit the irritation caused by medications such as tazarotene and anthralin.

Update on Drugs and Drug News: January 2001

Update on: Lamivudine, Zidovudine and Abacavir Trizivir Loratidine Claritin Amlexanox 5% paste AptheraBotulinum toxin type B Myobloc

The Use Of Interleukins For Advanced Melanoma

Treatment of metastatic melanoma using traditional chemotherapy regimens has been disappointing. However, recent work with agents that modify the host’s immune system (e.g., interleukins) have provided limited but encouraging results. Interleukins are a group of molecules involved in immune cell signaling.

Topical Tacrolimus

Currently, tacrolimus is emerging as a promising therapeutic alternative for the treatment of a number of dermatological diseases that have in common an aberrant immunologic response. This topical ointment is the first of its kind to be approved by the US FDA (December 2000), 0.1% for the treatment of moderate-to-severe atopic dermatitis in adults, and 0.03% for children older than 2 years of age and for adults who are undergoing long-term intermittent therapy.

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